磁気で体内治療を誘導するバイオ素材開発(Making Magnetic Biomaterials)

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2025-04-29 ピッツバーグ大学

磁気で体内治療を誘導するバイオ素材開発(Making Magnetic Biomaterials)

ピッツバーグ大学の研究チームは、磁性を持つバイオマテリアルの開発に成功しました。この新素材は、医療分野において、細胞の操作や組織再生、ドラッグデリバリーシステムなどへの応用が期待されています。研究者たちは、生体適合性の高いポリマーと磁性ナノ粒子を組み合わせることで、外部磁場によって制御可能なバイオマテリアルを作製しました。この技術により、体内での精密な治療や再生医療の進展が見込まれます。

<関連情報>

酸化鉄ナノ粒子の化学的コンジュゲーションによる磁気誘導可能なシルク粒子の開発 Chemical Conjugation of Iron Oxide Nanoparticles for the Development of Magnetically Directable Silk Particles

Ande X. Marini,Golnaz N. Tomaraei,Justin S. Weinbaum,Mostafa Bedewy,and David A. Vorp
ACS Applied Materials & Interfaces  Published: February 3, 2025
DOI:https://doi.org/10.1021/acsami.4c17536

Abstract

Magnetically directable materials containing iron oxide nanoparticles (IONPs) have been utilized for a variety of medical applications, including localized drug delivery. Regenerated silk fibroin (RSF) has also been used in numerous regenerative medicine and drug delivery applications, given its biocompatibility and tunable properties. In this work, we explored the hypothesis that chemically conjugating IONPs to RSF to anchor the IONPs to silk microparticles would provide better magnetic guidance than nonconjugated IONPs untethered to silk microparticles. IONPs were fabricated using a coprecipitation method and conjugated with glutathione (GSH) prior to mixing with RSF. IONPs incorporated into RSF were mixed with potassium phosphate buffer to fabricate microparticles. IONPs with and without GSH were characterized for particle size, shape, morphology, GSH conjugation efficiency, and composition. Silk iron microparticles (SIMPs) were also characterized for particle size, shape, and composition and tested for stability, degradation properties, magnetic movability, and cytotoxicity. IONPs demonstrated a uniform size distribution and spherical morphology. Conjugation of IONPs with GSH was verified through changes in the X-ray photoelectron spectroscopy (XPS) and Fourier-transform infrared spectroscopy (FTIR) spectra. IONPs and RSF were able to be chemically conjugated and fabricated into SIMPs, which demonstrated a spherical and porous morphology. FTIR revealed an increased β-sheet content in SIMPs, suggesting that the IONPs may be inducing conformational changes in the silk fibroin. SIMPs showed stability up to 4 weeks in ultrapure water and rapid enzymatic degradation within 24 h. SIMPs were able to be moved magnetically through solution and through a hydrogel and were not cytotoxic.

生物工学一般
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