2025-05-08 カロリンスカ研究所(KI)
<関連情報>
- https://news.ki.se/vitamin-supplements-slow-down-the-progression-of-glaucoma
- https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00200-9
緑内障の神経保護にビタミンB6、B9、B12、コリンが有効であることが一炭素代謝異常によって明らかになった Dysfunctional one-carbon metabolism identifies vitamins B6, B9, B12, and choline as neuroprotective in glaucoma
James R. Tribble ∙ Vickie H.Y. Wong ∙ Kelsey V. Stuart ∙ … ∙ Anthony P. Khawaja ∙ Bang V. Bui ∙ Pete A. Williams
Cell Reports Medicine Published:May 8, 2025
DOi:https://doi.org/10.1016/j.xcrm.2025.102127
Graphical abstract
Highlights
- Elevated retinal homocysteine is a pathogenic feature of glaucoma
- One-carbon metabolism is dysregulated in glaucoma
- Oral B6, B9, B12, and choline is neuroprotective in animal models
Summary
Glaucoma, characterized by the loss of retinal ganglion cells (RGCs), is a leading cause of blindness for which there are no neuroprotective therapies. To explore observations of elevated homocysteine in glaucoma, we elevate vitreous homocysteine, which increases RGC death by 6% following ocular hypertension. Genetic association with higher homocysteine does not affect glaucoma-associated outcomes from the UK Biobank and serum homocysteine levels have no effect on glaucomatous visual field progression. This supports a hypothesis in which elevated homocysteine is a pathogenic, rather than causative, feature of glaucoma. Further exploration of homocysteine metabolism in glaucoma animal models demonstrates early and sustained dysregulation of genes involved in one-carbon metabolism and the interaction of essential cofactors and precursors (B6, B9, B12, and choline) in whole retina and optic nerve head and RGCs. Supplementing these provides neuroprotection in an acute model and prevents neurodegeneration and protects visual function in a chronic model of glaucoma.
