2025-05-13 イェール大学
Illustration by Michael S. Helfenbein
<関連情報>
- https://news.yale.edu/2025/05/13/new-study-offers-insights-designing-safe-effective-nasal-vaccines
- https://www.nature.com/articles/s41590-025-02156-0
粘膜アジュバントブースターワクチンはマウスにおいて既存免疫の転換により局所IgA応答を誘発する Mucosal unadjuvanted booster vaccines elicit local IgA responses by conversion of pre-existing immunity in mice
Dong-il Kwon,Tianyang Mao,Benjamin Israelow,Keyla Santos Guedes de Sá,Huiping Dong & Akiko Iwasaki
Nature Immunology Published:13 May 2025
DOI:https://doi.org/10.1038/s41590-025-02156-0
Abstract
Mucosal delivery of vaccine boosters induces robust local protective immune responses even without any adjuvants. Yet, the mechanisms by which antigen alone induces mucosal immunity in the respiratory tract remain unclear. Here we show that an intranasal booster with an unadjuvanted recombinant SARS-CoV-2 spike protein, after intramuscular immunization with 1 μg of mRNA–LNP vaccine encoding the full-length SARS-CoV-2 spike protein (Pfizer/BioNTech BNT162b2), elicits protective mucosal immunity by retooling the lymph node-resident immune cells. On intranasal boosting, peripheral lymph node-primed B cells rapidly migrated to the lung through CXCR3–CXCL9 and CXCR3–CXCL10 signaling and differentiated into antigen-specific IgA-secreting plasma cells. Memory CD4+ T cells in the lung served as a natural adjuvant for developing mucosal IgA by inducing the expression of chemokines CXCL9 and CXCL10 for memory B cell recruitment. Furthermore, CD40 and TGFβ signaling had important roles in mucosal IgA development. Repeated mucosal boosting with an unadjuvanted protein amplified anamnestic IgA responses in both the upper and the lower respiratory tracts. These findings help explain why nasal boosters do not require an adjuvant to induce robust mucosal immunity at the respiratory mucosa and can be used to design safe and effective vaccines against respiratory pathogens.
