脳活動における薬物関連刺激の偏りを映画で検出(Academy Award-Nominated Movie Helps Researchers Identify Brain Region Biased Towards Drug Cues and Treatment Effects)

ad

2025-05-14 マウントサイナイ医療システム(MSHS)

脳活動における薬物関連刺激の偏りを映画で検出(Academy Award-Nominated Movie Helps Researchers Identify Brain Region Biased Towards Drug Cues and Treatment Effects)

Graphical representation of the study. Image credit: Mount Sinai Health System

マウントサイナイ医科大学の研究チームは、映画『トレインスポッティング』を用いて、ヘロイン使用障害(HUD)患者の脳活動を分析。報酬や意思決定に関わる眼窩前頭皮質(OFC)が薬物関連の映像に対して強く反応し、患者が薬物刺激に注意と動機づけを集中させる傾向が明らかになりました。治療後にはこの反応が正常化。自然な映像刺激を活用した本研究は、依存症治療の個別化や介入法開発に寄与する可能性があります。

<関連情報>

薬物をテーマとした映画に対する眼窩前頭葉の共有動態がヘロイン中毒における渇望と回復を追跡する Shared orbitofrontal dynamics to a drug-themed movie track craving and recovery in heroin addiction

Greg Kronberg , Ahmet O Ceceli , Yuefeng Huang , Pierre-Olivier Gaudreault , Sarah G King , Natalie McClain , Nelly Alia-Klein , Rita Z Goldstein
Brain  Published:12 November 2024
DOI:https://doi.org/10.1093/brain/awae369

Abstract

Movies captivate groups of individuals (the audience), especially if they contain themes of common motivational interest to the group. In drug addiction, a key mechanism is maladaptive motivational salience attribution whereby drug cues outcompete other reinforcers within the same environment or context. We predicted that while watching a drug-themed movie, where cues for drugs and other stimuli share a continuous narrative context, functional MRI responses in individuals with heroin use disorder (iHUD) will preferentially synchronize during drug scenes.

Thirty inpatient iHUD (24 male) and 25 healthy controls (16 male) watched a drug-themed movie at baseline and at follow-up after 15 weeks.

Results revealed such drug-biased synchronization in the orbitofrontal cortex (OFC), ventromedial and ventrolateral prefrontal cortex, and insula. After 15 weeks during ongoing inpatient treatment, there was a significant reduction in this drug-biased shared response in the OFC, which correlated with a concomitant reduction in dynamically-measured craving, suggesting synchronized OFC responses to a drug-themed movie as a neural marker of craving and recovery in iHUD.

医療・健康
ad
ad
Follow
ad
タイトルとURLをコピーしました