2025-06-10 カリフォルニア大学サンディエゴ校 (UCSD)
<関連情報>
- https://today.ucsd.edu/story/cutting-edge-technology-expands-dictionary-of-human-metabolism
- https://www.cell.com/cell/fulltext/S0092-8674(25)00565-3
マイクロバイオームが長鎖脂肪酸から短鎖脂肪酸由来のN-アシル脂質に多様化する The microbiome diversifies long- to short-chain fatty acid-derived N-acyl lipids
Helena Mannochio-Russo ∙ Vincent Charron-Lamoureux ∙ Martijn van Faassen ∙ … ∙ Dionicio Siegel ∙ Rob Knight ∙ Pieter C. Dorrestein
Cell Published:June 10, 2025
DOI:https://doi.org/10.1016/j.cell.2025.05.015
Graphical abstract
Highlights
- MS/MS data mining enables the creation of an N-acyl lipid spectral library resource
- Short-chain fatty acid-derived N-acyl lipids are described
- N-acyl histamines and cadaverines are linked to HIV and neurocognitive impairment
- N-acyl cadaverines show immunomodulatory effects of T cells
Summary
N-Acyl lipids are important mediators of several biological processes including immune function and stress response. To enhance the detection of N-acyl lipids with untargeted mass spectrometry-based metabolomics, we created a reference spectral library retrieving N-acyl lipid patterns from 2,700 public datasets, identifying 851 N-acyl lipids that were detected 356,542 times. 777 are not documented in lipid structural databases, with 18% of these derived from short-chain fatty acids and found in the digestive tract and other organs. Their levels varied with diet and microbial colonization and in people living with diabetes. We used the library to link microbial N-acyl lipids, including histamine and polyamine conjugates, to HIV status and cognitive impairment. This resource will enhance the annotation of these compounds in future studies to further the understanding of their roles in health and disease and to highlight the value of large-scale untargeted metabolomics data for metabolite discovery.
