2025-08-01 大阪公立大学
図:フソバクテリウム(白矢印)とフィーカリバクテリウム(黄矢印)が相互作用する様子を捉えた電子顕微鏡像
<関連情報>
- https://www.omu.ac.jp/info/research_news/entry-18697.html
- https://www.omu.ac.jp/assets/attachmentfile/attachmentfile-file-74952.pdf
- https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-025-02168-w
フソバクテリウム・バリアムとフェカリバクテリウム・プラウスニッツィイ間の代謝物介在型相互作用と直接接触 Metabolite-mediated interactions and direct contact between Fusobacterium varium and Faecalibacterium prausnitzii
Koji Hosomi,Satoko Maruyama,Tsubasa Matsuoka,Mari Furuta,Yoko Tojima,Keita Uchiyama,Makiko Morita,Hitoshi Kawashima,Toshiki Kobayashi & Jun Kunisawa
Microbiome Published:DOI:https://doi.org/10.1186/s40168-025-02168-w
Abstract
Background
The human gut harbors a diverse microbiota that is crucial for maintaining health but also contributes to several diseases. Understanding how microbial communities are assembled and maintained is critical for advancing gut health.
Results
We identified a unique interaction between the pathobiont Fusobacterium varium and the symbiont Faecalibacterium prausnitzii, both members of the gut microbial community; their interaction is driven by metabolites and direct cell-to-cell contact. Growth of F. varium was inhibited in the presence of F. prausnitzii because of a decrease in pH and an increase in β-hydroxybutyric acid. Conversely, the growth of F. prausnitzii was promoted in the presence of F. varium, likely via direct contact.
Conclusions
These findings highlight the importance of metabolite-driven interactions and direct contact in shaping gut microbial communities and emphasize the potential of interactions between F. prausnitzii and F. varium in influencing gut health.
