2025-08-08 東京科学大学
図1:横軸は遺伝的な2型糖尿病のリスク、縦軸は2型糖尿病のオッズ比を示す。
遺伝的なリスクの高い人は、フルーツジュースを週に1回以上摂取する(点線)と、摂取しない人(実線)に比べて、2型糖尿病のオッズ比が低いことが分かる。
<関連情報>
- https://www.isct.ac.jp/ja/news/s1adtohc5y43
- https://www.isct.ac.jp/plugins/cms/component_download_file.php?type=2&pageId=&contentsId=1&contentsDataId=2069&prevId=&key=4bd676ba6b1a6cc57b447822ca33cca7.pdf
- https://doi.org/10.1017/S0007114525103863
2型糖尿病の遺伝的リスクが高い個人における果物ジュース摂取と2型糖尿病の逆相関:日本多施設共同コホート研究(J-MICC) Inverse association between fruit juice consumption and type 2 diabetes among individuals with high genetic risk on type 2 diabetes: the Japan Multi-Institutional Collaborative Cohort (J-MICC) study
Tomoki Kawahara,Nobutoshi Nawa,Isao Oze,Hiroaki Ikezaki,Megumi Hara,Yoko Kubo,Mako Nagayoshi,Hidemi Ito,Nobuaki Michihata and Rie Ibusuki,…
British Journal of Nutrition Published:10 July 2025
DOI:https://doi.org/10.1017/S0007114525103863
Abstract
Previous studies on the association between fruit juice consumption and type 2 diabetes remain controversial, which might be due to heterogeneity in the polygenic risk score (PRS) for type 2 diabetes. We examined the association between fruit juice and type 2 diabetes by PRS for type 2 diabetes. We investigated whether fruit juice influences type 2 diabetes risk differently among individuals with varying genetic risks. Data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study, a cross-sectional study of 13 769 Japanese individuals was used for our analysis. The primary exposure was the frequency of fruit juice, categorised as do not drink, less than 1 cup per day or more than 1 cup per day. We selected PGS002379, a PRS for type 2 diabetes developed using East Asian populations. The primary outcome was physician-diagnosed type 2 diabetes, reported by participants. The consumption of fruit juice was significantly inversely associated with type 2 diabetes in the group with a high PRS for type 2 diabetes (OR: 0·78, 95 % CI: 0·65, 0·93 for < 1 cup/d and OR: 0·54, 95 % CI: 0·30, 0·96 for > 1/d), but this association was not observed in the low PRS group. Fruit juice consumption was inversely associated with type 2 diabetes, especially in genetically high-risk populations for type 2 diabetes.
