2025-08-13 マウントサイナイ医療システム (MSHS)
<関連情報>
- https://www.mountsinai.org/about/newsroom/2025/a-mount-sinailed-team-creates-model-for-understanding-how-the-brains-decisionmaking-is-impacted-in-psychiatric-disorders
- https://www.nature.com/articles/s41467-025-61466-x
意思決定空間モデルが文脈に応じた意思決定を説明 A decision-space model explains context-specific decision-making
Dirk W. Beck,Cory N. Heaton,Luis D. Davila,Lara I. Rakocevic,Sabrina M. Drammis,Danil Tyulmankov,Atanu Giri,Shreeya Umashankar Beck,Qingyang Zhang,Michael Pokojovy,Kenichiro Negishi,Alexis A. Salcido,Neftali F. Reyes,Andrea Y. Macias,Serina A. Batson,Paulina Vara,Raquel J. Ibáñez Alcalá,Safa B. Hossain,Graham L. Waller,Laura E. O’Dell,Travis M. Moschak,Ki A. Goosens & Alexander Friedman
Nature Communications Published:14 August 2025
DOI:https://doi.org/10.1038/s41467-025-61466-x
Abstract
Optimal decision-making requires consideration of internal and external contexts. Biased decision-making is a transdiagnostic symptom of neuropsychiatric disorders. We created a computational model demonstrating how the striosome compartment of the striatum constructs a context-dependent mathematical space for decision-making computations, and how the matrix compartment uses this space to define action value. The model explains multiple experimental results and unifies other theories like reward prediction error, roles of the direct versus indirect pathways, and roles of the striosome versus matrix, under one framework. We also found, through new analyses, that striosome and matrix neurons increase their synchrony during difficult tasks, caused by a necessary increase in dimensionality of the space. The model makes testable predictions about individual differences in disorder susceptibility, decision-making symptoms shared among neuropsychiatric disorders, and differences in neuropsychiatric disorder symptom presentation. The model provides evidence for the central role that striosomes play in neuroeconomic and disorder-affected decision-making.
