2025-08-19 ミュンヘン大学(LMU)
<関連情報>
- https://www.lmu.de/en/newsroom/news-overview/news/new-approaches-for-cancer-therapy-first-tumor-treatment-with-radioactive-ion-beams.html
- https://www.nature.com/articles/s41567-025-02993-8
放射性イオンビームを用いたマウス腫瘍の画像誘導治療 Image-guided treatment of mouse tumours with radioactive ion beams
Daria Boscolo,Giulio Lovatti,Olga Sokol,Tamara Vitacchio,Martina Moglioni,Francesco Evangelista,Emma Haettner,Walter Tinganelli,Christian Graeff,Uli Weber,Christoph Schuy,Munetaka Nitta,Daria Kostyleva,Sivaji Purushothaman,Peter G. Thirolf,Andreas Bückner,Jonathan Bortfeldt,Christoph Scheidenberger,Katia Parodi & Marco Durante
Nature Physics Published:19 August 2025
DOI:https://doi.org/10.1038/s41567-025-02993-8
Abstract
Charged particle therapy with protons or heavier ions is one of the most effective radiotherapy techniques, but uncertainties in the beam range can limit its efficacy. Radioactive ion beams are ideal for image-guided particle therapy because isotopes that undergo β+ decay can be visualized with positron emission tomography. This allows spatial localization of the particle distribution in vivo, which can be correlated with the expected dose deposition for online beam range verification. Here we report the successful treatment of a mouse osteosarcoma using a radioactive 11C-ion beam. The tumour was located in the neck, close to the spinal cord, where deviations of even a few millimetres in the beam range could lead to unintended dose deposition in the spine and radiation-induced myelopathy, an injury to the spinal cord. We achieved complete tumour control with the highest dose of 20 Gy while avoiding paralysis. Low-grade neurological side effects were correlated to the activity measured by positron emission tomography in the spine. The biological washout of the activity from the tumour volume was dependent on the dose, indicating a potential component of vascular damage at high doses. This experiment marks a step towards future clinical applications of radioactive ion beams.
