2025-09-25 カロリンスカ研究所(KI)
<関連情報>
- https://news.ki.se/increased-risk-of-depression-and-psychosis-after-childbirth-among-mothers
- https://www.nature.com/articles/s41380-025-03212-9
- https://www.nature.com/articles/s41562-025-02311-5
妊娠前、妊娠中、産後の母親の精神疾患:スウェーデンにおける全国コホート研究 Maternal psychiatric disorders before, during, and after pregnancy: a national cohort study in Sweden
Emma Bränn,Jerry Guintivano,Yihui Yang,Louise Lundborg,Marion Opatowski,Fang Fang,Unnur A. Valdimarsdóttir,Emma Fransson,Alkistis Skalkidou,Yi Lu & Donghao Lu
Molecular Psychiatry Published:25 September 2025
DOI:https://doi.org/10.1038/s41380-025-03212-9
Abstract
Maternal mental health is a critical public health issue, yet the evidence on rates of incident psychiatric disorders before, during, and after pregnancy is limited. This study aimed to describe the calendar time trends and characterize and compare the risk of maternal psychiatric disorders before, during, and after pregnancy. Leveraging the national and regional registers in Sweden, we conducted a cohort study of all women who gave birth 2003–2019 in Sweden (1,799,010 pregnancies from 1,052,977 women). We identified any incident diagnosis of psychiatric disorders recorded during three periods: the preconceptional year, pregnancy, and the postpartum year. We calculated age and calendar year standardized incidence rate (SIR) of psychiatric disorders annually, and by week across three periods. We further estimated the incidence rate ratio (IRR) using the rate during corresponding preconceptional weeks as the reference. The SIR of maternal psychiatric disorder overall increased from 2003–2019, especially for preconceptional disorders. During the preconceptional year the weekly SIR of any psychiatric disorder was stable at around 25 per 1000 person-years. The SIR gradually decreased during pregnancy to a minimum of 4 per 1000 person-years and bounced back to the preconceptional levels during the postpartum year. This trend was similar in all subtypes of psychiatric disorders, except for depression and psychosis for which an increase was noted at 5–15 and 0–20 postpartum weeks, respectively. An increased incidence rate of maternal psychiatric disorder diagnosed before, during, and after pregnancy was found over time. Our findings suggest an increased risk of depression and psychosis shortly after delivery, although a lowered risk of other psychiatric disorders during and after pregnancy, compared to before pregnancy.
スウェーデンにおける妊娠中および出産後の親の自殺未遂リスクの男女差 Sex difference in parental risk of suicide attempt during and after pregnancy in Sweden
Yihui Yang,Emma Bränn,Emma Fransson,Krisztina D. László,Fang Fang,Fotios C. Papadopoulos,Unnur A. Valdimarsdóttir,Alkistis Skalkidou & Donghao Lu
Nature Human Behaviour Published:25 September 2025
DOI:https://doi.org/10.1038/s41562-025-02311-5
Abstract
Whether the risks of maternal and paternal suicide attempt during and after pregnancy differ remains unclear. Here, in this nationwide register-based study in Sweden (2,196,276 pregnancies), we defined the year before conception, pregnancy and the year after birth and estimated week-specific incidence rate ratios (IRRs). We identified 7,469 (1.39 per 1,000 person-years) suicide attempts among mothers and 8,338 (1.62 per 1,000 person-years) among fathers. Compared with the corresponding week in the preconception period, mothers had a lower risk of suicide attempt during and after pregnancy (with the lowest IRR of 0.14 (0.11–0.17) at first week postpartum); fathers’ risk of suicide attempt remained largely stable before childbirth, but a lower risk was observed during the first 10 postpartum weeks (IRRs ranging from 0.69 (0.58–0.81) to 0.91 (0.84–0.99)), followed by a higher risk in the later postpartum period (IRRs ranging from 1.10 (1.01–1.21) to 1.72 (1.33–2.24)). Compared with fathers, mothers had a lower risk of suicide attempt during and after pregnancy (for example, IRR of 0.22 (0.18–0.28) at first week postpartum). Compared with the general population, the sex difference of suicide attempt is reversed during and after pregnancy, suggesting pregnancy or childbirth may have a more pronounced association with suicide attempt among mothers than fathers.
