2025-09-25 バース大学
Web要約 の発言:
The team analysed the DNA from bacterial samples as far back as 1917, before antibiotics were discovered, to see how they had evolved since.
<関連情報>
- https://www.bath.ac.uk/announcements/capturing-100-years-of-antibiotic-resistance-evolution/
- https://www.science.org/doi/10.1126/science.adr1522
抗生物質以前と以後の時代:抗菌薬耐性の歴史的広がり Pre- and postantibiotic epoch: The historical spread of antimicrobial resistance
Adrian Cazares, Wendy Figueroa, Daniel Cazares, Leandro Lima, […] , and Nicholas R. Thomson
Science Published:25 Sep 2025
DOI:https://doi.org/10.1126/science.adr1522
Abstract
Plasmids are now the primary vectors of antimicrobial resistance, but our understanding of how human industrialisation of antibiotics influenced their evolution is limited by a paucity of data predating the antibiotic era (PAE). By investigating plasmids from clinically relevant bacteria sampled and isolated between 1917 and 1954 and comparing them to modern plasmids, we have captured over 100 years of evolution. We show that while virtually all PAE plasmids were devoid of resistance genes and most never acquired them, a minority evolved to drive the global spread of resistance to first line and last resort antibiotics in Gram-negative bacteria. Modern plasmids have evolved through complex microevolution and fusion events into a distinct group of highly recombinogenic, multi-replicon, self-transmissible plasmids that now pose the highest risk to resistance dissemination, and therefore to human health.
