近年急増する「花粉食物アレルギー症候群」17歳で1割以上に発症～交差反応でりんご、キウイに特に注意～

2025-10-21 成育医療研究センター

【図1:花粉食物アレルギー症候群(PFAS)の有症率と感作状況】

<関連情報>

• https://www.ncchd.go.jp/press/2025/1021.html
• https://www.ncchd.go.jp/press/assets/1021.pdf
• https://www.jaci-global.org/article/S2772-8293(25)00162-6/fulltext

東京の青少年における花粉食物アレルギー症候群の有病率と感作 Prevalence and sensitization of pollen–food allergy syndrome among adolescents in Tokyo

Tomoyuki Kiguchi, MD^a ∙ Tomoki Yaguchi, MD^a ∙ Tatsuki Fukuie, MD, PhD^a ∙ Yukihiro Ohya, MD, PhD^a,b,c,d ∙ Kiwako Yamamoto-Hanada, MD, PhD
Journal of Allergy and Clinical Immunology: Global  Published:August 28, 2025
DOI:https://doi.org/10.1016/j.jacig.2025.100561

Abstract

Background

Allergic rhinitis and pollen sensitization typically increase with age; however, longitudinal data on the prevalence of pollen–food allergy syndrome (PFAS) among Japanese adolescents are limited.

Objective

We assessed the prevalence, causal foods, and sensitization status of PFAS among 17-year-olds and explored its association with comorbid allergic conditions.

Methods

This study was conducted as part of the Tokyo Child Health, Disease, and Development Research, a prospective birth cohort study involving the general population. Adolescents aged 17 (range, 16-18) years participated in a cross-sectional survey that included a medical history and health questionnaire, alongside serum IgE testing by ImmunoCAP ISAC. Statistical analyses were performed by descriptive statistics.

Results

Among 458 participants, 54.4% had current pollen allergy and 11.2% had PFAS. The most common causal foods were apples (45.1%), kiwis (41.2%), and pineapples (39.2%). Sensitization rates were high for Cry j 1 (96.1%), Bet v 1 (70.6%), Mal d 1 (64.7%), and Pru p 1 (62.7%). Additionally, 43.1% of adolescents with PFAS had a history of atopic dermatitis, suggesting a link between PFAS and the concept of the allergic march. Rhinitis symptoms peaked in spring, with 79.8% reporting symptoms, particularly in March and April.

Conclusion

This study examined the prevalence and sensitization status of PFAS among Japanese adolescents. PFAS was common in those with pollen allergies and was associated with atopic dermatitis, supporting the allergic march hypothesis. Apples, kiwis, and pineapples were the most frequently implicated foods. These findings underscore the importance of recognizing PFAS in managing adolescent allergic conditions.