子どもの肥満リスク評価に特化した初の身体スキャンチャートを開発(New Concordia-led study develops the first child-specific body scan charts to assess obesity risk)

2025-10-29

2025-10-23 カナダ・コンコルディア大学

コンコルディア大学を中心とする研究チームは、子どもの肥満リスクをより正確に評価するため、世界初の年齢・性別別の体脂肪・筋肉成長曲線を開発した。従来のBMIでは脂肪と筋肉の区別ができないため、研究者らは6,000人超の米国児童のDXA(全身X線吸収測定)データを分析し、脂肪量と筋肉量を独立評価。その上でケベック州の追跡調査データに適用し、低脂肪・高筋肉(LA-HM)、高脂肪・高筋肉(HA-HM)、低脂肪・低筋肉(LA-LM)、高脂肪・低筋肉(HA-LM)の4タイプを定義した。特にHA-LM群はサルコペニック肥満の危険が最も高く、善玉コレステロール低下やインスリン抵抗性上昇など心代謝疾患の初期兆候が見られた。本研究は小児と成人の評価指標のギャップを埋める初の成果であり、肥満・糖尿病予防の早期介入や個別化医療に貢献が期待される。成果は『Pediatric Obesity』誌に掲載。

<関連情報>

心臓代謝リスク予測のための二重エネルギーX線吸収測定データからの子供の性別と年齢別の脂肪量と筋肉量の基準曲線の開発と応用 Development and Application of Children’s Sex- and Age-Specific Fat-Mass and Muscle-Mass Reference Curves From Dual-Energy X-Ray Absorptiometry Data for Predicting Cardiometabolic Risk

Stephanie Tanasia Saputra, Andraea Van Hulst, Mélanie Henderson, Simone Brugiapaglia, Claudia Faustini, Lisa Kakinami
Pediatric Obesity Published: 29 August 2025
DOI:https://doi.org/10.1111/ijpo.70051

ABSTRACT

Background

A dual-energy x-ray absorptiometry (DXA)-derived phenotype classification based on fat mass and muscle mass has been developed for adults. We extended this to a paediatric population.

Methods

Children’s (≤ 17 years) DXA data in NHANES (n = 6120) were used to generate sex- and age-specific deciles of appendicular skeletal muscle mass index and fat mass index with the Lambda Mu Sigma method. Four phenotypes (high [H] or low [L], adiposity [A] and muscle mass [M]: HA-HM, HA-LM, LA-HM, LA-LM) were identified based on being above/below the median compared to same-sex and same-age peers. These reference curves were applied to the QUALITY cohort (n = 630, 8–10 years of age in 2005) to assess whether the phenotypes correctly identified cardiometabolic risk at baseline, follow-up (2008–2010), and their longitudinal changes. Multiple linear regression models were adjusted for age, sex, and Tanner’s stage.

Results

Compared to the LA-HM reference group, the HA-HM phenotype was associated with less favourable HDL, triglycerides, and HOMA-IR at baseline and first follow-up, but not in their changes. The HA-LM phenotype was associated with less favourable HOMA-IR at baseline and first follow-up.