2025-11-19 スウォンジー大学
<関連情報>
- https://www.swansea.ac.uk/press-office/news-events/news/2025/11/new-nanogel-technology-destroys-drug-resistant-bacteria-in-hours.php
- https://onlinelibrary.wiley.com/doi/10.1002/anie.202513121
緑膿菌に対する強力な阻害剤としてのヘテロ多価ナノゲル Heteromultivalent Nanogels as Highly Potent Inhibitors of Pseudomonas Aeruginosa
Yuhang Jiang, Dr. Chuanxiong Nie, Boyu Zheng, Dr. Vinod Khatri, Denis Puccio, Yanping Long, Dr. Mathias Dimde, Prof. Dr. Rainer Haag, Dr. Sumati Bhatia
Angewandte Chemie International Edition Published: 11 November 2025
DOI:https://doi.org/10.1002/anie.202513121
Graphical Abstract
A heteromultivalent polyglycerol nanogel system integrates fucose/galactose and short-chain antibacterial peptides to achieve strong bactericidal and anti-biofilm effects at low concentration by efficient multivalent binding with bacterial lectins.
Abstract
The increasing prevalence of microbial resistance requires new antibacterial concepts for selective targeting and killing of pathogenic bacteria. Here, we report the synthesis of a heteromultivalent nanogel system against Pseudomonas aeruginosa (P. aeruginosa). These nanogels are based on biocompatible polyglycerols and functionalized with sugar ligands fucose (Fuc) or galactose (Gal) for P. aeruginosa targeting. With a further modification of these nanogels with BMAP-18 short chain peptides (GRFKRFRKKFKKLFKKLS), we have achieved > 99.99% inactivation of planktonic and > 99.9% inactivation of biofilm-coated P. aeruginosa within 12 h of treatment. Additionally, the system demonstrates broad-spectrum antimicrobial potential, effectively inhibiting Escherichia coli (E. coli) and Methicillin-resistant Staphylococcus aureus (MRSA). This modular design offers a promising strategy for the development of next-generation antimicrobial therapies targeting biofilm-associated infections and MDR bacteria.
