2026-01-13 カロリンスカ研究所(KI)
<関連情報>
- https://news.ki.se/fat-surrounding-the-colon-interacts-with-the-immune-system
- https://www.sciencedirect.com/science/article/pii/S155041312500539X
細胞構造マルチデポプロファイリングによりヒト結腸関連脂肪組織における免疫代謝クロストークが明らかに Cytoarchitectural multi-depot profiling reveals immune-metabolic crosstalk in human colon-associated adipose tissue
Jutta Jalkanen, Jiawei Zhong, Pamela A. Nono Nankam, Nayanika Bhalla, Merve Elmastas, Jiaxin Luo, Sophie Weinbrenner, Scott Frendo-Cumbo, Benedek Pesti, William Gourash, Anita Courcoulas, Zinger Yang Loureiro, Arne Dietrich, Jesper Bäckdahl, Anders Thorell, Marcus Buggert, Joanna Kalucka, Margo P. Emont, Evan D. Rosen, Matthias Blüher,…,Niklas Mejhert
Cell Metabolism Available online: 13 January 2026.
DOI:https://doi.org/10.1016/j.cmet.2025.12.008
Graphical abstract
Highlights
- Spatial and single-nucleus mapping reveal diversity across human adipose depots
- Epiploic fat is enriched in immune cells and serum amyloid-positive adipocytes
- Inflammatory cues induce adipocyte serum amyloid A expression
- Visceral fat near the colon exhibits immune-metabolic specialization
Summary
While it is well established that the cellular composition of white adipose tissue (WAT) varies between depots, the functional relevance of this heterogeneity remains unclear. By combining spatial and single-nucleus RNA sequencing, we provide a comprehensive map of subcutaneous and visceral (omental, mesenteric, mesocolic, and epiploic) WAT in both men and women. Our analyses reveal shared features, such as the spatial organization of adipogenesis, alongside depot-specific characteristics, including distinct cell-type enrichments and unique cell-cell communication routes. Epiploic WAT stands out by harboring high proportions of serum amyloid A expressing fat cells (encoded by SAA1/SAA2) and several leukocyte populations. Through mechanistic studies, we demonstrate that adipocyte SAA1/SAA2 expression is induced by inflammatory signals, including lipopolysaccharide, and that SAA1 activates immune responses in adipose-resident myeloid cells. Collectively, our findings suggest that visceral WAT exhibits distinct cytoarchitectural properties, with those located near the colon adapting by developing specialized adipocytes and immune cell populations.
