2026-04-03 北海道大学, 環境健康科学研究教育センター, エコチル調査北海道ユニットセンター
＜関連情報＞
- https://www.hokudai.ac.jp/news/pdf/260403_pr3.pdf
- https://www.sciencedirect.com/science/article/pii/S0013935126001672
胎児期における有機リン系農薬への曝露と4歳児の湿疹およびアレルギー性鼻結膜炎との関連性：日本環境と子どもに関する研究 Associations of prenatal exposure to organophosphate pesticides with eczema and allergic rhinoconjunctivitis in 4-year-old children: The Japan Environment and Children’s Study
Megasari Marsela, Hiroyoshi Iwata, Yu Ait Bamai, Mariko Itoh, Rahel Mesfin Ketema, Takeshi Yamaguchi, Yasuaki Saijo, Yoshiya Ito, Sachiko Itoh, Keiko Yamazaki, Naomi Tamura, Keitaro Makino, Maki Tojo, Reiko Kishi, Atsuko Ikeda, the Japan Environment and Children’s Study Group
Environmental Research Available online: 3 February 2026
DOI:https://doi.org/10.1016/j.envres.2026.123839
Highlights
- This study examined the association between prenatal OPPs and eczema, AR in children.
- Six DAPs were measured in first-trimester urine; only three were used in analyses.
- DMP were associated with a higher risk of eczema in children aged 4 years old.
- Association between DMTP and eczema was confined to children with lower IgE levels.
- Higher DMTP levels may be linked to a tendency toward non-atopic (intrinsic) eczema.
Abstract
Purpose
This study aimed to evaluate the associations of prenatal exposure to organophosphate pesticides (OPP) with eczema and allergic rhinoconjunctivitis (AR) in 4-year-old Japanese children.
Methods
The participants in this study were Sub-Cohorts of the Japan Environment and Children’s Study (JECS). The maternal urinary OPP metabolite concentrations of six dialkylphosphates (DAPs) were measured by lipid chromatography coupled with tandem mass spectrometry, corrected by specific gravity. Eczema and AR cases were defined according to the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire for children at 4 years old. Multiple logistic regression analysis was used to examine the associations of DAPs with eczema and AR. Sub-group analyses were performed to explore the association between DAP metabolites and AR and eczema in children with elevated (≥170 IU/mL) and lower (<170 IU/mL) serum IgE levels.
Results
Data from 4218 participants were analyzed. The highest DAP concentration was observed in the dimethylthiophosphate (DMTP) (Median: 3.33 ng/ml). Out of the six measured OPP metabolites, only 3 could be used for the analyses. There were positive associations of dimethylphosphate (DMP) (adjusted OR = 1.30; 95%CI = 1.06-1.59; FDR-adjusted p = 0.048) with eczema. No associations were found with AR or IgE alone. Sub-group analysis revealed a positive association between DMTP and eczema in children with lower IgE levels (<170 IU/mL) (adjusted OR = 1.28; 95%CI = 1.04-1.57; p = 0.02).
Conclusion
Prenatal DMP and DMTP were associated with an increased risk of eczema in children aged 4, with this association confined to children with DMTP and lower IgE levels, while no associations were found with AR or IgE levels.
