2026-04-07 ワシントン州立大学（WSU）
＜関連情報＞
- https://news.wsu.edu/press-release/2026/04/07/turmeric-ginger-extract-shows-benefits-for-bone-implants/
- https://ceramics.onlinelibrary.wiley.com/doi/10.1111/jace.70532
荷重支持型インプラント用、クルクミンおよびショウガ抽出物配合ZnOヒドロキシアパタイトコーティングTi-6Al-4V ZnO-Hydroxyapatite-Coated Ti-6Al-4V With Curcumin and Ginger Extract for Load-Bearing Implants
Arjak Bhattacharjee, Ujjayan Majumdar, William S. Dernell, Amit Bandyopadhyay, Susmita Bose
Journal of the American Ceramic Society Published: 11 February 2026
DOI:https://doi.org/10.1111/jace.70532
ABSTRACT
There is a rising trend in the number of clinical cases related to bone implantation and bone cancer across the globe due to longer life expectancy, accidents, and sports-related injuries. In this study, we have used curcumin and ginger extract as alternate osseointegrating agents with in vitro osteosarcoma inhibition potential for load-bearing, site-specific delivery after direct incorporation on the plasma-sprayed ZnO-doped hydroxyapatite (HA)-coated Ti-6Al-4V. Successful parametric optimization during coating can lead to thickness of 80–150 µm. The in vivo efficacy of this novel localized delivery vehicle for initial-stage osseointegration is tested with a rat distal femur model. Various histological evaluations with Masson–Goldner, hematoxylin and eosin (H&E), and Sanderson rapid bone staining (SRBS) indicate up to ∼2 times greater new bone formation surrounding the drug-loaded implants than the control group. The in vitro results indicate that curcumin and ginger extract reduce MG-63 osteosarcoma cell viability on the implant surface by 11-fold. The assessment of antibacterial properties against Staphylococcus aureus (S. aureus) shows ∼92% efficacy of the treatment samples. After osteosarcoma surgery, these localized drug delivery vehicles can find applications in load-bearing defect repair sites.
