2023-06-12 カロリンスカ研究所(KI)
◆この研究は、より効果的なワクチンの開発など、科学的な可能性を持っています。
<関連情報>
- https://news.ki.se/new-method-enables-study-of-nano-sized-particles
- https://www.nature.com/articles/s41587-023-01825-5
単一粒子プロファイラによるナノサイズのバイオ粒子の含有量と特性のハイスループット測定 High-throughput measurement of the content and properties of nano-sized bioparticles with single-particle profiler
Taras Sych,Jan Schlegel,Hanna M. G. Barriga,Miina Ojansivu,Leo Hanke,Florian Weber,R. Beklem Bostancioglu,Kariem Ezzat,Herbert Stangl,Birgit Plochberger,Jurga Laurencikiene,Samir El Andaloussi,Daniel Fürth,Molly M. Stevens & Erdinc Sezgin
Nature Biotechnology Published:12 June 2023
DOI:https://doi.org/10.1038/s41587-023-01825-5
Abstract
We introduce a method, single-particle profiler, that provides single-particle information on the content and biophysical properties of thousands of particles in the size range 5–200 nm. We use our single-particle profiler to measure the messenger RNA encapsulation efficiency of lipid nanoparticles, the viral binding efficiencies of different nanobodies, and the biophysical heterogeneity of liposomes, lipoproteins, exosomes and viruses.
