2023-07-03 カリフォルニア大学リバーサイド校(UCR)
◆リノール酸が大豆油の主な懸念事項であり、過剰な摂取は腸内細菌叢に悪影響を及ぼします。この研究から、オリーブオイルの摂取が健康的であり、大豆油よりも安全であることが示されました。大豆油の摂取量を管理し、加工食品を避けることが重要です。
<関連情報>
- https://news.ucr.edu/articles/2023/07/03/widely-consumed-vegetable-oil-leads-unhealthy-gut
- https://www.tandfonline.com/doi/full/10.1080/19490976.2023.2229945
リノール酸を多く含む食事は腸内カンナビノイド系を調節し、マウスの大腸炎感受性を高める Diet high in linoleic acid dysregulates the intestinal endocannabinoid system and increases susceptibility to colitis in Mice
Poonamjot Deol,Paul Ruegger,Geoffrey D. Logan,Ali Shawki,Jiang Li,Jonathan D. MitchellJacqueline Yu,Varadh Piamthai,Sarah H. Radi,Sana Hasnain,Kamil Borkowski,John W. Newman,Declan F. McCole,Meera G. Nair,Ansel Hsiao,James Borneman & Frances M. Slade
Gut Microbes Published: 03 Jul 2023
DOI:https://doi.org/10.1080/19490976.2023.2229945
ABSTRACT
Inflammatory bowel disease (IBD) is a multifactorial disease with increasing incidence in the U.S. suggesting that environmental factors, including diet, are involved. It has been suggested that excessive consumption of linoleic acid (LA, C18:2 omega-6), which must be obtained from the diet, may promote the development of IBD in humans. To demonstrate a causal link between LA and IBD, we show that a high fat diet (HFD) based on soybean oil (SO), which is comprised of ~55% LA, increases susceptibility to colitis in several models, including IBD-susceptible IL10 knockout mice. This effect was not observed with low-LA HFDs derived from genetically modified soybean oil or olive oil. The conventional SO HFD causes classical IBD symptoms including immune dysfunction, increased intestinal epithelial barrier permeability, and disruption of the balance of isoforms from the IBD susceptibility gene Hepatocyte Nuclear Factor 4α (HNF4α). The SO HFD causes gut dysbiosis, including increased abundance of an endogenous adherent invasive Escherichia coli (AIEC), which can use LA as a carbon source. Metabolomic analysis shows that in the mouse gut, even in the absence of bacteria, the presence of soybean oil increases levels of LA, oxylipins and prostaglandins. Many compounds in the endocannabinoid system, which are protective against IBD, are decreased by SO both in vivo and in vitro. These results indicate that a high LA diet increases susceptibility to colitis via microbial and host-initiated pathways involving alterations in the balance of bioactive metabolites of omega-6 and omega-3 polyunsaturated fatty acids, as well as HNF4α isoforms.
