2023-12-18 パデュー大学
◆これにより、植物はストレスや病原体攻撃に対抗するために必要な代謝物質を必要な時に生成し、不要な時には生成しないようになっています。また、生成しすぎることが遺伝子の調整を乱す可能性があり、これについての理解が深まれば、植物が特殊な代謝物質を効果的に生産し、耐性向上や医薬品合成、受粉の促進などへの応用が期待されます。
<関連情報>
- https://www.purdue.edu/newsroom/releases/2023/Q4/plant-metabolism-proves-more-complicated-than-previously-understood.html
- https://www.cell.com/trends/plant-science/fulltext/S1360-1385(23)00258-3
もう十分だ:特殊な代謝のフィードバック制御 Enough is enough: feedback control of specialized metabolism
Ying Li,Erich Grotewold,Natalia Dudareva
Trends in Plant Science Published:August 23, 2023
DOI:https://doi.org/10.1016/j.tplants.2023.07.012
Highlights
- Specialized metabolic pathways are highly regulated.
- This regulation includes feedback inhibition of the transcriptional machinery by pathway intermediates or products.
- Specialized metabolites can be sensed by numerous mechanisms, impacting multiple levels of transcriptional regulation, thus leading to major changes in gene expression.
- The regulatory effect of specialized metabolites involves other aspects of gene expression, in addition to transcription.
Abstract
Recent advances in our understanding of plant metabolism have highlighted the significance of specialized metabolites in the regulation of gene expression associated with biosynthetic networks. This opinion article focuses on the molecular mechanisms of small-molecule-mediated feedback regulation at the transcriptional level and its potential modes of action, including metabolite signal perception, the nature of the sensor, and the signaling transduction mechanisms leading to transcriptional and post-transcriptional regulation, based on evidence available from plants and other kingdoms of life. We also discuss the challenges associated with identifying the occurrences, effects, and localization of small molecule–protein interactions. Further understanding of small-molecule-controlled metabolic fluxes will enable rational design of transcriptional regulation systems in metabolic engineering to produce high-value specialized metabolites.
