合成素材が腸内マイクロバイオーム研究の簡便性とコスト削減を改善する可能性(Synthetic material could improve ease and cut cost of gut microbiome research)

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2024-03-27 ペンシルベニア州立大学(PennState)

ペンシルベニア州立大学の研究チームが開発した新しい合成材料、フッ素補助粘液代用物(FAMS)は、微生物と消化器系の相互作用を研究するのを容易にし、薬剤が腸内感染や代謝性疾患、炎症性腸疾患にどのように影響するかを探るための手段を提供する可能性がある。この材料は安価で手に入りやすく、マウスモデルに頼らずに研究が進められる。将来的には、3Dプリント技術を活用したカスタマイズ可能な腸組織の開発も期待される。

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合成大腸粘液がモジュール型マイクロバイオーム・オーガノイドの開発を可能にする Synthetic Colonic Mucus Enables the Development of Modular Microbiome Organoids

Michael A. Miller, Scott Medina
Advanced Functional Materials  Published: 13 March 2024
DOI:https://doi.org/10.1002/adfm.202402514

合成素材が腸内マイクロバイオーム研究の簡便性とコスト削減を改善する可能性(Synthetic material could improve ease and cut cost of gut microbiome research)

Abstract

The human colon is home to trillions of microorganisms that modulate gastrointestinal physiology. The understanding of how this gut ecosystem impacts human health, although evolving, is slowed by the lack of accessible tools suitable to studying complex host-mucus-microbe interactions. Here, a synthetic gel-like material capable of recapitulating the varied structural, mechanical, and biochemical profiles of native human colonic mucus is reported to develop compositionally simple microbiome screening platforms with utility in microbiology and drug discovery. The viscous fibrillar material is realized through templated assembly of a fluorine-rich amino acid at liquid-liquid interphases. The fluorine-assisted mucus surrogate (FAMS) can be decorated with mucins to serve as a habitat for microbial colonization and integrated with human colorectal cells to generate artificial mucosae, referred to as a microbiome organoid. Notably, FAMS are made with inexpensive and commercially available materials and can be generated using simple protocols and standard laboratory hardware. As a result, this platform can be broadly incorporated into various laboratory settings to advance probiotic research and inform in vivo approaches. If implemented into high throughput screening approaches, FAMS may represent a valuable tool to study compound metabolism and gut permeability, with an exemplary demonstration of this utility presented here.

生物工学一般
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