変性関節疾患のテクニカラー・イメージングを可能にする新しい技術(New technique allows technicolor imaging of degenerative joint disease)

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2024-10-25 ペンシルベニア州立大学(PennState)

ペンシルベニア州立大学の研究チームが、フォトンカウントCTスキャナーと新しいコントラスト剤を用いて、関節疾患の早期段階を可視化する技術を開発した。関節軟骨のタンパク質「アグリカン」と「アグリカナーゼ」を対象とし、これらの比率変化で関節症の進行度を追跡可能にする。この技術により、症状発現前の病変を検出でき、早期介入による治療が期待される。

<関連情報>

スペクトル光子計数CTを用いた二重バイオマーカーの比率測定追跡のためのプラセオジムとハフニウムからの標的Kエッジナノプローブ Targeted K-Edge Nanoprobes From Praseodymium and Hafnium for Ratiometric Tracking of Dual Biomarkers using Spectral Photon Counting CT

Nivetha Gunaseelan, Parikshit Moitra, Pranay Saha, Teresa Aditya, Mahdieh Moghiseh, Kevin Jonker, Steven Gieseg, Anthony Butler, Fadia Kamal, Dipanjan Pan
Advanced Science  Published: 07 October 2024
DOI:https://doi.org/10.1002/advs.202408408

変性関節疾患のテクニカラー・イメージングを可能にする新しい技術(New technique allows technicolor imaging of degenerative joint disease)

Abstract

Utilizing metal nanoprobes with unique K-edge identities to visualize complementary biological activities simultaneously can provide valuable information about complex biological processes. This study describes the design and preparation of an innovative pair of K-edge metal nanoprobes and demonstrates the feasibility of their simultaneous quantitative detection using spectral photon-counting computed tomography (SPCCT). Glycosaminoglycan (GAG) capped nanoparticles (ca. 15–20 nm) targeting two distinct components of the cartilage tissue, namely, aggrecan (acan) and aggrecanase (acanase) are designed and synthesized. These targeted nanoparticles comprised of praseodymium (Pr) and hafnium (Hf), with well-separated K-edge energies, enable simultaneous and ratiometric imaging of dual biomarkers in cartilage tissue. Following extensive physico-chemical characterization of the ligand-targeted particles, the feasibility of homing dual biomarkers in vitro is demonstrated. The material discrimination and simultaneous quantification of these targeted particles are also achieved and corroborated with inductively coupled plasmon spectroscopy. For the first time, the use of praseodymium is reported as a contrast agent for SPCCT imaging and demonstrates the ability to pair it with hafnium nanoprobes for multicontrast imaging of diseases. Importantly, the potential for ratiometric molecular imaging and tracking of osteoarthritis (OA) progression is shown with SPCCT K-edge based imaging approach.

医療・健康
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