2025-03-12 バース大学
<関連情報>
- https://www.bath.ac.uk/announcements/integrating-stopping-smoking-support-into-talking-therapies-helps-more-people-quit-new-study/
- https://onlinelibrary.wiley.com/doi/10.1111/add.16718
抑うつと不安に対する通常の心理学的ケアの一環としての禁煙治療の統合(ESCAPE): 多施設共同無作為化比較試験、質的手法のネストによる受容性と実現可能性の試験 intEgrating Smoking Cessation treatment As part of usual Psychological care for dEpression and anxiety (ESCAPE): A randomised and controlled, multi-centre, acceptability and feasibility trial with nested qualitative methods
Gemma M. J. Taylor, Katherine Sawyer, Pamela Jacobsen, Tom P. Freeman, Anna Blackwell, Shadi Daryan, Chris Metcalfe, David Kessler, Marcus R. Munafò, Paul Aveyard
Addiction Published: 11 March 2025
DOI:https://doi.org/10.1111/add.16718
Abstract
Background and aim
There is evidence that smoking cessation may improve depression and anxiety symptoms. We assessed the feasibility of implementing and trialling a smoking cessation intervention in services providing cognitive behavioural therapy (CBT) for common mental illness.
Design, setting and participants
This study was a pragmatic, two-armed, randomised, multi-centre, acceptability and feasibility trial of a co-designed smoking cessation intervention (ISRCTN99531779) involving United Kingdom National Health Service (NHS)-funded services treating depression or anxiety among four NHS Trusts. Participants comprised adult daily smokers starting CBT for depression or anxiety [mean age 35.6 years, standard deviation (SD) = 12.7, 89.6% white] who smoked 14.3 (SD = 8.2) cigarettes/day with mean Generalised Anxiety Disorder Questionnaire-7 (GAD-7) and Patient Health Questionnaire-9 (PHQ-9) scores of 13.1 (SD = 4.9) and 14.5 (SD = 6.0). Sixty-eight participants were allocated to the treatment group and 67 to control.
Intervention and control
Both groups received CBT for depression or anxiety. The treatment group also received up to 12 sessions of integrated smoking cessation support. The control group was signposted to smoking cessation services post-treatment.
Measurements
Follow-up was at 3 and 6 months. The primary outcome was ‘study completion’ by 3 months. Other outcomes included acceptability, satisfaction, feasibility, data completeness and mental health.
Findings
At 3 months, treatment did not affect study completion [odds ratio (OR) = 0.81, 95% confidence interval (CI) = 0.31 to 2.09], did not harm mental health (PHQ-9 difference: coefficient 0.01, 95% CI = -2.19 to 2.22); GAD-7: coefficient 0.65, 95% CI = -1.59 to 2.90), but increased abstinence rates (OR = 8.69, 95% CI = 1.11 to 396.26). Recruitment was acceptable and key stakeholders were satisfied with the intervention.
Conclusions
Among UK adult smokers receiving CBT treatment for depression or anxiety, a smoking cessation intervention within the CBT treatment was well received, did not interfere with the primary treatment goals and increased smoking cessation.
