2025-07-08 マックス・プランク研究所(MPI)
To stay in balance, the brain depends on two types of neurons: Excitatory neurons (in white), which increase activity, and inhibitory neurons (in black), which damp down signals. Scientists have now uncovered that inhibitory neurons born later in development mature faster, a process that is guided by specific genes. © MPI for Biological Intelligence/ Julia Kuhl
<関連情報>
- https://www.mpg.de/25033665/making-up-for-lost-time-inhibitory-neurons-catch-up-during-brain-development
- https://www.nature.com/articles/s41593-025-01999-y
マウスのGABAニューロン発生における前駆細胞能力の時間的制御が成熟を形成する Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice
Ann Rose Bright,Yana Kotlyarenko,Florian Neuhaus,Diana Rodrigues,Chao Feng,Christian Peters,Ilaria Vitali,Elif Dönmez,Michael H. Myoga,Elena Dvoretskova & Christian Mayer
Nature Neuroscience Published:08 July 2025
DOI:https://doi.org/10.1038/s41593-025-01999-y
Abstract
Diverse types of GABAergic projection neuron and interneurons of the telencephalon derive from progenitors in a ventral germinal zone called the ganglionic eminence. Using single-cell transcriptomics, chromatin accessibility profiling, lineage tracing, birthdating, transplantation across developmental stages and perturbation sequencing in mouse embryos, we investigated how progenitor competence influences the maturation and differentiation of these neurons. We found that the temporal progression of neurogenesis shapes maturation competence in ganglionic eminence progenitors, influencing how their progeny progress toward mature states. By contrast, differentiation competence—defined as the ability of progenitors to produce diverse transcriptomic identities—was maintained throughout neurogenesis. Chromatin remodeling, together with a regulatory module composed of the transcription factor NFIB and its target genes, influenced maturation competence in late-born neurons. These findings reveal how transcriptional programs and chromatin accessibility govern neuronal maturation and the diversification of GABAergic neuron subtypes during neurodevelopment.
