2025-08-08 京都大学
グルココルチコイドはTh17細胞の分化と増殖を促して腸管炎症を悪化させる。
<関連情報>
- https://www.kyoto-u.ac.jp/ja/research-news/2025-08-08-0
- https://www.kyoto-u.ac.jp/sites/default/files/2025-08/web_2508_Ikuta-37500caa0153fabf36fea1bd3fc5546e.pdf
- https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00864-2
ストレス誘発性グルココルチコイドは、Th17細胞の分化を促進することで急性炎症を強化する Stress-induced glucocorticoids enhance acute inflammation by promoting the differentiation of Th17 cells
Akihiro Shimba ∙ Guangwei Cui ∙ Shinya Abe ∙ … ∙ Hideki Ueno ∙ Hiroshi Ohno ∙ Koichi Ikuta
Cell Reports Published:August 2, 2025
DOI:https://doi.org/10.1016/j.celrep.2025.116093
Highlights
- Glucocorticoids (GCs) promote the glycolysis and differentiation of Th17 cells
- GCs maintain the survival of peripheral Th17 cells via Bcl2 upregulation
- Stress-induced GCs expand Th17 cells expressing lower levels of TCF1
- Stress-induced GCs enhance IL-17 production and the recruitment of neutrophils
Summary
Stress can trigger acute inflammation by increasing the pro-inflammatory cytokine interleukin (IL)-17 for injury and infection, while inducing the production of the immunosuppressive hormone glucocorticoids (GCs). However, the mechanism through which stress-induced GCs enhance acute inflammation by directly regulating the development of IL-17-producing helper T (Th17) cells remains unclear. Here, we demonstrate that GCs promote Th17 cell differentiation and survival in both mice and humans. Stress-induced GCs augment the expansion of Th17 cells expressing low levels of TCF1, a negative regulator of IL-17 expression. In addition, GCs promote Th17 cell differentiation by enhancing glycolysis. Stress-induced GCs also increase IL-17 production and neutrophil recruitment in the intestine upon bacterial antigen stimulation. Moreover, the expansion of Th17 cells mediated by stress-induced GCs exacerbates acute colitis by promoting IL-17 production and neutrophil recruitment. Thus, stress promotes acute inflammation by enhancing the differentiation of Th17 cells through GCs, which may contribute to self-defense against infections.
