2025-09-19 国立成育医療研究センター
<関連情報>
- https://www.ncchd.go.jp/press/2025/0919.html
- https://www.ncchd.go.jp/press/assets/0919.pdf
- https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgaf446/8223077
幼少期における粒子状物質曝露と甲状腺ホルモン濃度の関連性:JECS研究の結果 Association Between Particulate Matter Exposure and Thyroid Hormone Levels in Early Childhood: Results From JECS
Limin Yang, Miori Sato, Mayako Saito-Abe, Yumiko Miyaji, Daisuke Harama, Kei Sakamoto, Minaho Nishizato, Natsuhiko Kumasaka, Hidetoshi Mezawa, Kiwako Yamamoto-Hanada …
The Journal of Clinical Endocrinology & Metabolism Published:06 August 2025
DOI:https://doi.org/10.1210/clinem/dgaf446
Abstract
Background
Particulate matter (PM) exposure is associated with adverse health outcomes. However, the association between PM exposure and thyroid hormone concentrations in children has not been comprehensively evaluated.
Objectives
Using an ongoing birth cohort dataset, the association between PM exposure and blood free T4 (fT4) and TSH concentrations in children aged 2 to 4 years was assessed.
Methods
Data were obtained from the Japan Environment and Children’s Study. Children aged 2 years and those aged 4 years were analyzed separately, with 3599 and 3431 cases included in each dataset. The generalized linear model and the quantile g-computation models were fitted.
Results
Neither indoor nor outdoor PM exposures at 1.5 years were significantly associated with fT4 and TSH levels at 2 years of age. Indoor and outdoor PM10-2.5 exposures at 3 years of age were negatively associated with fT4 concentrations at 4 years of age. A simultaneous increase in PM concentrations by 1 quartile at 3 years of age resulted in a significant decrease in fT4 levels of 0.011 ng/dL at 4 years of age.
Conclusion
Using a large sample, the statistical modeling results suggested an opposite association between PM exposure and fT4. However, since this association is very weak, from a clinical and epidemiological point of view, we can entirely ignore the effect of PM exposure on fT4. Therefore, we conclude that PM does not significantly influence thyroid parameters in daily life.
