2025-10-29 バッファロー大学(UB)
<関連情報>
- https://www.buffalo.edu/news/releases/2025/10/UB-Bisson-NEJM-exercise-eases-knee-pain.html
- https://www.nejm.org/doi/full/10.1056/NEJMoa2503385
半月板断裂と膝の痛みに対する理学療法のランダム化試験 A Randomized Trial of Physical Therapy for Meniscal Tear and Knee Pain
Jeffrey N. Katz, M.D., Jamie E. Collins, Ph.D., Leslie Bisson, M.D., Morgan H. Jones, M.D., M.P.H., James J. Irrgang, Ph.D., P.T., Faith Selzer, Ph.D., Clare E. Safran-Norton, P.T., Ph.D., +24 , and Elena Losina, Ph.D.
New England Journal of Medicine Published: October 29, 2025
DOI: 10.1056/NEJMoa2503385
Abstract
Background
Physical therapy is routinely recommended for knee pain attributed to a degenerative meniscal tear, but its efficacy has not been established.
Methods
We randomly assigned participants 45 to 85 years of age with knee pain, osteoarthritis, and meniscal tear to one of four groups: home exercise (3-month home-exercise program), home exercise plus text messages to encourage exercise adherence, home exercise plus text messages plus sham physical therapy (in-clinic sham manual therapy and sham ultrasound therapy), and home exercise plus text messages plus standard physical therapy (supervised strengthening, functional, and stretching exercises and manual therapy). The primary outcome was the change in the Knee Injury and Osteoarthritis Outcome Score (KOOS) pain subscore (range, 0 to 100, with higher scores indicating more pain) between baseline and 3 months, with adjustment for trial site, baseline KOOS pain subscore, and radiographic grade.
Results
A total of 879 participants underwent randomization (mean [±SD] age, 59.2±7.8 years). The difference in the 3-month change in the KOOS pain subscore between home exercise and home exercise plus text messages was -0.1 points (98.3% confidence interval [CI], -3.8 to 3.7) and between home exercise and home exercise plus text messages plus standard physical therapy was 2.5 points (98.3% CI, -1.3 to 6.2); the difference between home exercise plus text messages and home exercise plus text messages plus standard physical therapy was 2.5 points (98.3% CI, -1.4 to 6.5). Adverse events were generally nonserious and evenly distributed overall across groups.
Conclusions
For patients with degenerative meniscal tear and knee pain, the addition of physical therapy or text messages to encourage adherence to home exercises was not superior in reducing pain to a home-exercise program alone. (Funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases and others; TeMPO ClinicalTrials.gov number, NCT03059004.)
