2026-02-09 東北大学
図1. リンパ節の中に新しく見つかった「抜け道」を示しています。
<関連情報>
- https://www.tohoku.ac.jp/japanese/2026/02/press20260209-01-lymph.html
- https://www.tohoku.ac.jp/japanese/newimg/pressimg/tohokuuniv-press20260209_01web_lymph.pdf
- https://pathsocjournals.onlinelibrary.wiley.com/doi/10.1002/path.70032
リンパ管トポロジーは新たなリンパ節内リンパ静脈シャントを明らかにする Lymphatic topology reveals a novel intranodal lympho-venous shunt
Ariunbuyan Sukhbaatar, Mishra Radhika, Akira Nakamura, Mori Shiro, Tsuyoshi Sugiura, Tetsuya Kodama
The Journal of Pathology Published: 04 February 2026
DOI:https://doi.org/10.1002/path.70032
Abstract
Understanding the lymphatic network is crucial for immunological research. Currently, a complete map of lymphatic drainage in mice is lacking. We present a detailed lymphatic system flow dynamic of two mouse strains with swollen lymph nodes (LNs), using region-specific tracer injection and high-resolution micro-CT imaging to characterize LN volume, weight, density, and spatial topology. No significant differences were observed in LN localization or numbers by strain or sex. Notably, we identified previously unreported drainage pathways and asymmetries, including distinct right and left lymphatic flows. We also discovered intranodal lympho-venous shunts in LNs, which facilitate unidirectional fluid transport and prevent interstitial fluid buildup and edema. Our findings suggest that these shunts may play a significant role in the delivery of therapeutics within LNs and highlight the need for further research into lymphatic structure–function relationships. © 2026 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.
