2022-03-22 ペンシルベニア州立大学(PennState)
・マウスを用いた低侵襲な手術で、ワイヤレスの生分解性デバイスをマウスの脳深部に挿入しました。この装置は、重要な神経伝達物質であるドーパミンのレベルや、pHレベル、温度、電気生理など脳の他の特性に関するデータを収集し、無害化されて体内に戻される。
・神経伝達物質を検出する生分解性センサーは、医師がさまざまな治療や手術に使用できる可能性がある。
<関連情報>
- https://www.psu.edu/news/institute-computational-and-data-sciences/story/biodegradable-implant-could-help-doctors-monitor/
- https://pubmed.ncbi.nlm.nih.gov/35073597/
シリコンナノメンブレンと2次元材料のヘテロインテグレーションによる生体吸収型ワイヤレス神経化学システムの開発 Hetero-Integration of Silicon Nanomembranes with 2D Materials for Bioresorbable, Wireless Neurochemical System
Seung Min Yang 1, Jae Hyung Shim 1, Hyun-U Cho 2, Tae-Min Jang 1, Gwan-Jin Ko 1, Jeongeun Shim 2, Tae Hee Kim 3, Jia Zhu 4, Sangun Park 3 5, Yoon Seok Kim 1, Su-Yeon Joung 1, Jong Chan Choe 1, Jeong-Woong Shin 1, Joong Hoon Lee 1, Yu Min Kang 2, Huanyu Cheng 4, Youngmee Jung 3 6 7, Chul-Ho Lee 1 8, Dong Pyo Jang 2, Suk-Won Hwang 1 8
PMID: 35073597 DOI: 10.1002/adma.202108203
Adv Mater. 2022 Jan 24;e2108203. doi: 10.1002/adma.202108203. Online ahead of print.
Abstract:
図S1. 代表的なデバイスの写真。
(a) 代表的なデバイスの全体像を示す写真である。代表的なデバイスの寸法と機械的な柔軟性。
(b) 光学顕微鏡による神経プローブの各構成要素
(左:ドーパミンセンサー、中:pHセンサー、右は温度計)。
Although neurotransmitters are key substances closely related to evaluating degenerative brain diseases as well as regulating essential functions in the body, many research efforts have not been focused on direct observation of such biochemical messengers, rather on monitoring relatively associated physical, mechanical, and electrophysiological parameters. Here, a bioresorbable silicon-based neurochemical analyzer incorporated with 2D transition metal dichalcogenides is introduced as a completely implantable brain-integrated system that can wirelessly monitor time-dynamic behaviors of dopamine and relevant parameters in a simultaneous mode. An extensive range of examinations of molybdenum/tungsten disulfide (MoS2 /WS2 ) nanosheets and catalytic iron nanoparticles (Fe NPs) highlights the underlying mechanisms of strong chemical and target-specific responses to the neurotransmitters, along with theoretical modeling tools. Systematic characterizations demonstrate reversible, stable, and long-term operational performances of the degradable bioelectronics with excellent sensitivity and selectivity over those of non-dissolvable counterparts. A complete set of in vivo experiments with comparative analysis using carbon-fiber electrodes illustrates the capability for potential use as a clinically accessible tool to associated neurodegenerative diseases.
Keywords: 2D materials; bioresorbable materials; neurochemical systems; silicon nanomembranes.
© 2022 Wiley-VCH GmbH.
