2022-05-09 ノースカロライナ州立大学(NCState)
Photo by Ken Reid on Unsplash.
<関連情報>
- https://news.ncsu.edu/2022/05/cognitive-decline-in-dogs-alzheimers-disease/
- https://content.iospress.com/articles/journal-of-alzheimers-disease/jad215562
高齢化した愛犬集団における認知機能障害の定量化を目的とした認知機能検査、質問票、血漿バイオマーカーの使用について Use of Cognitive Testing, Questionnaires, and Plasma Biomarkers to Quantify Cognitive Impairment in an Aging Pet Dog Population
Fefer, Gilad; Panek, Wojciech K; Khan, Michael Z.; Singer, Matthew; Westermeyer, Hans; Mowat, Freya M.; Murdoch, David M.; Case, Beth; Olby, Natasha J.; Gruen, Margaret E
Journal of Alzheimer’s Disease Published: 15 April 2022
DOI: 10.3233/JAD-215562
Abstract
Background:Aging dogs suffer from canine cognitive dysfunction syndrome (CCDS), a condition in which cognitive decline is associated with amyloid pathology and cortical atrophy. Presumptive diagnosis is made through physical examination, exclusion of systemic/metabolic conditions, and completion of screening questionnaires by owners. Objective:This study aimed to determine whether cognitive function could be quantified in aging pet dogs, and to correlate cognitive testing with validated questionnaires and plasma neurofilament light chain (pNfL) concentration in aging dogs. Methods:Thirty-nine dogs from fifteen breeds were recruited (9.3 to 15.3 years). Owners completed the Canine Dementia Scale (CADES) and Canine Cognitive Dysfunction Rating scale (CCDR). Executive control and social cues were tested, and pNfL was measured with single molecule array assay. Comparisons were made between cognitive testing scores, CADES, CCDR scores, and pNfL. Results:CADES scoring classified five dogs as severe CCDS, six as moderate, ten as mild, and eighteen as normal. CCDR identified seven dogs at risk of CCDS and thirty-two as normal. Cognitive testing was possible in the majority of dogs, although severely affected dogs were unable to learn tasks. CADES score correlated with sustained attention duration (r = –0.47, p = 0.002), inhibitory control (r = –0.51, p = 0.002), detour (r = –0.43, p = 0.001), and pNfL (r = 0.41, p = 0.025). Concentration of pNfL correlated with inhibitory control (r = –0.7, p≤0.001). The CCDR scale correlated with performance on inhibitory control (r = –0.46, p = 0.005). Conclusion:Our findings suggest that a multi-dimensional approach using a combination of questionnaires, specific cognitive tests, and pNfL concentration can be used to quantify cognitive decline in aging pet dogs.
