2023-05-01 ワシントン大学セントルイス校
◆ワシントン大学医学部の研究者たちは、マウスを用いた研究で、ストレスが脳に与える影響が異なることを示し、女性マウスの場合、アミロイドβタンパク質のレベルが急激に上昇することが明らかになった。さらに、女性マウスの脳細胞には男性マウスには存在しない分子経路が存在し、ストレスに対する反応の違いが説明できることも示された。
◆性差が健康や病気に影響を与えることが分かり、女性は男性に比べストレスにより高いリスクを抱えることも明らかになった。女性は、男性に比べてストレスによる影響を受けやすく、アルツハイマー病などの予防や治療にどのように反応するかを理解することが重要である。
<関連情報>
- https://source.wustl.edu/2023/05/stress-increases-alzheimers-risk-in-female-mice-but-not-males/
- https://medicine.wustl.edu/news/stress-increases-alzheimers-risk-in-female-mice-but-not-males/
- https://academic.oup.com/brain/advance-article-abstract/doi/10.1093/brain/awad052/7097860
雄雌マウスにおける急性ストレスのアミロイドβに対する性差の影響 Sex-dependent effects of acute stress on amyloid-β in male and female mice
Hannah M Edwards, Clare E Wallace, Woodrow D Gardiner, Brookelyn M Doherty, Ryan T Harrigan, Kayla M Yuede, Carla M Yuede, John R Cirrito
Brain Published:02 May 2023
DOI:https://doi.org/10.1093/brain/awad052
Abstract
The risk of developing Alzheimer’s disease is mediated by a combination of genetics and environmental factors, such as stress, sleep abnormalities and traumatic brain injury. Women are at a higher risk of developing Alzheimer’s disease than men, even when controlling for differences in lifespan. Women are also more likely to report high levels of stress than men. Sex differences in response to stress may play a role in the increased risk of Alzheimer’s disease in women.
In this study, we use in vivo microdialysis to measure levels of Aβ in response to acute stress in male and female mice. We show that Aβ levels are altered differently between female and male mice (APP/PS1 and wild-type) in response to stress, with females showing significantly increased levels of Aβ while most males do not show a significant change. This response is mediated through β-arrestin involvement in Corticotrophin Releasing Factor receptor signalling pathway differences in male and female mice as male mice lacking β-arrestin show increase in Aβ in response to stress similar to females.
