COVID-19のバリアントダイナミクスに関連する主要因を調べる研究(Research examines key factors related to COVID-19 variant dynamics)


2023-05-03 ロスアラモス国立研究所(LANL)



SARS-CoV-2のバリアント遷移ダイナミクスは、ワクチン接種率、共存する変異株数、回復期免疫と関連する SARS-CoV-2 variant transition dynamics are associated with vaccination rates, number of co-circulating variants, and convalescent immunity

Lauren J. Beesley,Kelly R. Moran,Kshitij Wagh,Lauren A. Castro,James Theiler,Hyejin Yoon,Will Fischer,Nick W. Hengartner,Bette Korber,Sara Y. Del Valle
eBioMedicine  Published:March 31, 2023

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Throughout the COVID-19 pandemic, the SARS-CoV-2 virus has continued to evolve, with new variants outcompeting existing variants and often leading to different dynamics of disease spread.

In this paper, we performed a retrospective analysis using longitudinal sequencing data to characterize differences in the speed, calendar timing, and magnitude of 16 SARS-CoV-2 variant waves/transitions for 230 countries and sub-country regions, between October 2020 and January 2023. We then clustered geographic locations in terms of their variant behavior across several Omicron variants, allowing us to identify groups of locations exhibiting similar variant transitions. Finally, we explored relationships between heterogeneity in these variant waves and time-varying factors, including vaccination status of the population, governmental policy, and the number of variants in simultaneous competition.

This work demonstrates associations between the behavior of an emerging variant and the number of co-circulating variants as well as the demographic context of the population. We also observed an association between high vaccination rates and variant transition dynamics prior to the Mu and Delta variant transitions.

These results suggest the behavior of an emergent variant may be sensitive to the immunologic and demographic context of its location. Additionally, this work represents the most comprehensive characterization of variant transitions globally to date.

Laboratory Directed Research and Development (LDRD), Los Alamos National Laboratory.