2023-10-02 ニューヨーク大学 (NYU)
◆インスリン様成長因子2(IGF2)はペリサイトから産生され、学習イベントに反応して増加し、神経活動に対応しており、記憶において神経細胞とペリサイトの協力が必要であることが示唆された。
◆この研究は、記憶の生物学に新しい視点を提供し、ペリサイトと血管系が記憶およびその疾患にどのような役割を果たすかを理解するためにさらなる研究が必要である。
<関連情報>
- https://www.nyu.edu/about/news-publications/news/2023/october/in-forming-long-term-memories–vascular-cells-are-crucial.html
- https://www.sciencedirect.com/science/article/abs/pii/S0896627323006645
神経細胞の活動が長期記憶を形成するために周皮細胞からのIGF2発現を促進する Neuronal activity drives IGF2 expression from pericytes to form long-term memory
Kiran Pandey, Benjamin Bessière, Susan L. Sheng, Julian Taranda, Pavel Osten, Ionel Sandovici, Miguel Constancia, Cristina M. Alberini
Neuron Published: October 2, 2023
DOI:https://doi.org/10.1016/j.neuron.2023.08.030
Summary
Investigations of memory mechanisms have been, thus far, neuron centric, despite the brain comprising diverse cell types. Using rats and mice, we assessed the cell-type-specific contribution of hippocampal insulin-like growth factor 2 (IGF2), a polypeptide regulated by learning and required for long-term memory formation. The highest level of hippocampal IGF2 was detected in pericytes, the multi-functional mural cells of the microvessels that regulate blood flow, vessel formation, the blood-brain barrier, and immune cell entry into the central nervous system. Learning significantly increased pericytic Igf2 expression in the hippocampus, particularly in the highly vascularized stratum lacunosum moleculare and stratum moleculare layers of the dentate gyrus. Igf2 increases required neuronal activity. Regulated hippocampal Igf2 knockout in pericytes, but not in fibroblasts or neurons, impaired long-term memories and blunted the learning-dependent increase of neuronal immediate early genes (IEGs). Thus, neuronal activity-driven signaling from pericytes to neurons via IGF2 is essential for long-term memory.
