ラウンドアップ成分が慢性腎臓病の蔓延に関係か(Roundup Ingredient Connected to Epidemic Levels of Chronic Kidney Disease)

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2023-10-11 デューク大学(Duke)

◆スリランカの農村部では、数十年にわたり、原因不明の腎臓障害(CKDu)により、何万人もの人々が苦しんでいます。デューク大学の研究者らによる大規模な研究で、世界で最も広く使用されている除草剤「ラウンドアップ」の有効成分であるグリホサートが、その原因の一つである可能性が特定されました。
◆グリホサートは硬水中で長期間にわたり存在し、特にスリランカの一部地域でCKDuが流行していることが判明しました。この研究により、ラウンドアップの有害性についての警告が発せられました。

<関連情報>

高硬度飲料水中のグリホサートとフッ化物はスリランカにおける原因不明の慢性腎臓病(CKDu)と正の相関を示す Glyphosate and Fluoride in High-Hardness Drinking Water Are Positively Associated with Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka

Jake C. Ulrich, Kate Hoffman, T. D. K. S. C. Gunasekara, P. M. M. A. Sandamini, Brian P. Jackson, P. Mangala C. S. De Silva, Nishad Jayasundara, and P. Lee Ferguson
Environmental Science and Technology Letters  Published:September 13, 2023
DOI:https://doi.org/10.1021/acs.estlett.3c00504

Abstract

Abstract Image

Chronic kidney disease of uncertain etiology (CKDu) has emerged as a serious public health concern in farming communities globally, especially in Sri Lanka with 5%–20% of the adult population affected by the disease in CKDu-endemic regions. It is hypothesized that drinking water contamination of glyphosate in combination with water hardness and co-occurring trace elements contribute to CKDu in Sri Lanka. However, no studies to date have comprehensively examined this hypothesis. Here, we conducted a large field study to measure and compare drinking water chemical burden in CKDu-endemic areas with CKDu-nonendemic areas in rural Sri Lanka. Chemical measures of water quality included glyphosate, water hardness, and trace elements, including fluoride. Glyphosate was detected in 44% of endemic wells and 8% of nonendemic wells. Fluoride was detected in 99% of endemic wells and 80% of nonendemic wells. Logistic regression revealed that the presence of elevated glyphosate, fluoride, hardness, and vanadium in wells was positively associated with CKDu prevalence. The co-occurrence of glyphosate and high hardness indicate potential complexation of glyphosate in wells from CKDu-endemic areas. Collectively, our work represents the first definitive assessment of glyphosate presence in regions with geogenic high water hardness and fluoride and demonstrates a strong correlation with CKDu incidence.

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