革新的な脳刺激技術が脳障害の治療に有望視される(Revolutionary Brain Stimulation Technique Shows Promise for Treating Brain Disorders)

ad

2024-02-24 韓国基礎科学研究院(IBS)

IBSの研究チームが開発したLILFUSは、脳機能に長期的な変化をもたらす可能性がある新しい非侵襲的脳刺激技術。超音波を使用し、特定の脳領域を精密に刺激することで、学習や記憶のプロセス中に観察される脳波パターンを模倣する。この技術は、新しい運動スキルの獲得を促進し、脳卒中生存者や運動障害のリハビリ療法に応用される可能性がある。

<関連情報>

パターン化された超音波による脳波同調により、可塑性が長期間持続する Long-lasting forms of plasticity through patterned ultrasound-induced brainwave entrainment

HO-JEONG KIM, TIEN THUY PHAN, KEUNHYUNG LEE, JEONG SOOK KIM, […], AND JOO MIN PARK
Science Advances  Published:23 Feb 2024
DOI:https://doi.org/10.1126/sciadv.adk3198

Abstract

Achieving long-lasting neuronal modulation with low-intensity, low-frequency ultrasound is challenging. Here, we devised theta burst ultrasound stimulation (TBUS) with gamma bursts for brain entrainment and modulation of neuronal plasticity in the mouse motor cortex. We demonstrate that two types of TBUS, intermittent and continuous TBUS, induce bidirectional long-term potentiation or depression-like plasticity, respectively, as evidenced by changes in motor-evoked potentials. These effects depended on molecular pathways associated with long-term plasticity, including N-methyl-d-aspartate receptor and brain-derived neurotrophic factor/tropomyosin receptor kinase B activation, as well as de novo protein synthesis. Notably, bestrophin-1 and transient receptor potential ankyrin 1 play important roles in these enduring effects. Moreover, pretraining TBUS enhances the acquisition of previously unidentified motor skills. Our study unveils a promising protocol for ultrasound neuromodulation, enabling noninvasive and sustained modulation of brain function.

ad

医療・健康
ad
ad
Follow
ad
タイトルとURLをコピーしました