クローン病治療の迅速化につながる埋め込み型センサー(Implantable sensor could lead to timelier Crohn’s treatment)

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2024-03-18 ノースウェスタン大学

ノースウェスタン大学の科学者が、クローン病患者の炎症性発作を検出するための初のワイヤレス埋め込み型温度センサーを開発。センサーは長期的かつリアルタイムなモニタリングを提供し、炎症性発作による永久的な損傷を防ぐ可能性があります。マウスの研究で成功し、今後は人工の炎症性腸疾患条件でのセンサーの能力を評価する予定。

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慢性腸炎の長期モニタリングのための小型埋め込み型温度センサー Miniaturized implantable temperature sensors for the long-term monitoring of chronic intestinal inflammation

Surabhi R. Madhvapathy,Matthew I. Bury,Larry W. Wang,Joanna L. Ciatti,Raudel Avila,Yonggang Huang,Arun K. Sharma & John A. Rogers
Nature Biomedical Engineering  Published:18 March 2024
DOI:https://doi.org/10.1038/s41551-024-01183-w

クローン病治療の迅速化につながる埋め込み型センサー(Implantable sensor could lead to timelier Crohn’s treatment)

Abstract

Diagnosing and monitoring inflammatory bowel diseases, such as Crohn’s disease, involves the use of endoscopic imaging, biopsies and serology. These infrequent tests cannot, however, identify sudden onsets and severe flare-ups to facilitate early intervention. Hence, about 70% of patients with Crohn’s disease require surgical intestinal resections in their lifetime. Here we report wireless, miniaturized and implantable temperature sensors for the real-time chronic monitoring of disease progression, which we tested for nearly 4 months in a mouse model of Crohn’s-disease-like ileitis. Local measurements of intestinal temperature via intraperitoneally implanted sensors held in place against abdominal muscular tissue via two sutures showed the development of ultradian rhythms at approximately 5 weeks before the visual emergence of inflammatory skip lesions. The ultradian rhythms showed correlations with variations in the concentrations of stress hormones and inflammatory cytokines in blood. Decreasing average temperatures over the span of approximately 23 weeks were accompanied by an increasing percentage of inflammatory species in ileal lesions. These miniaturized temperature sensors may aid the early treatment of inflammatory bowel diseases upon the detection of episodic flare-ups.

医療・健康
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