2024-03-25 スイス連邦工科大学ローザンヌ校(EPFL)
<関連情報>
- https://actu.epfl.ch/news/the-proteins-that-shield-the-body-against-its-own-/
- https://www.cell.com/current-biology/abstract/S0960-9822(24)00232-X
体液性ストレス応答がショウジョウバエの組織を抗菌ペプチドから守る A humoral stress response protects Drosophila tissues from antimicrobial peptides
Samuel Rommelaere,Alexia Carboni,Juan F. Bada Juarez,…,Matteo Dal Peraro,Chan Cao,Bruno Lemaitre
Current Biology Published:March 13, 2024
DOI:https://doi.org/10.1016/j.cub.2024.02.049
Highlights
•Trachea expose phosphatidylserine, making them sensitive to AMPs
•Turandots are secreted proteins that protect the respiratory epithelium
•Turandots shield phosphatidylserine, preventing pore formation by AMPs
•Turandots favor Drosophila resilience to stress by preventing immunopathology
Summary
7An efficient immune system must provide protection against a broad range of pathogens without causing excessive collateral tissue damage. While immune effectors have been well characterized, we know less about the resilience mechanisms protecting the host from its own immune response. Antimicrobial peptides (AMPs) are small, cationic peptides that contribute to innate defenses by targeting negatively charged membranes of microbes. While protective against pathogens, AMPs can be cytotoxic to host cells. Here, we reveal that a family of stress-induced proteins, the Turandots, protect the Drosophila respiratory system from AMPs, increasing resilience to stress. Flies lacking Turandot genes are susceptible to environmental stresses due to AMP-induced tracheal apoptosis. Turandot proteins bind to host cell membranes and mask negatively charged phospholipids, protecting them from cationic pore-forming AMPs. Collectively, these data demonstrate that Turandot stress proteins mitigate AMP cytotoxicity to host tissues and therefore improve their efficacy.
Graphical abstract
