トラウマはどのように皮膚に浸透するか(How Trauma Gets Under the Skin)

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2024-04-15 カリフォルニア大学サンディエゴ校(UCSD)

トラウマはどのように皮膚に浸透するか(How Trauma Gets Under the Skin)
Traumatic experiences in early childhood can cause metabolic changes that impact muscle function later in life, according to new research co-authored by UC San Diego professor Anthony Molina. Photo credit: Nephron/Wikimedia Commons

幼少期のトラウマが後の人生で筋肉機能を損なう可能性があることを示す新しい研究が発表された。幼少期に逆境を経験した人々は、年配者において筋肉の代謝機能が低下する傾向があることが示された。この研究は、筋肉細胞内のミトコンドリアが生成するATP量を測定し、幼少期のトラウマとの関連性を明らかにした。

<関連情報>

小児期の有害なライフイベントと骨格筋ミトコンドリア機能 Childhood adverse life events and skeletal muscle mitochondrial function

KATE A. DUCHOWNY, DAVID J. MARCINEK, THERESA MAU, L. GRISELL DIAZ-RAMIERZ, […], AND ANTHONY J. A. MOLINA
Science Advances  Published:6 Mar 2024
DOI:https://doi.org/10.1126/sciadv.adj6411

Abstract

Social stress experienced in childhood is associated with adverse health later in life. Mitochondrial function has been implicated as a mechanism for how stressful life events “get under the skin” to influence physical well-being. Using data from the Study of Muscle, Mobility, and Aging (n = 879, 59% women), linear models examined whether adverse childhood events (i.e., physical abuse) were associated with two measures of skeletal muscle mitochondrial energetics in older adults: (i) maximal adenosine triphosphate production (ATPmax) and (ii) maximal state 3 respiration (Max OXPHOS). Forty-five percent of the sample reported experiencing one or more adverse childhood events. After adjustment, each additional event was associated with -0.08 SD (95% confidence interval = -0.13, -0.02) lower ATPmax. No association was observed with Max OXPHOS. Adverse childhood events are associated with lower ATP production in later life. Findings indicate that mitochondrial function may be a mechanism for understanding how early social stress influences health in later life.

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