2024-05-06 ハーバード大学
<関連情報>
- https://seas.harvard.edu/news/2024/05/expanding-lymph-node-boosting-vaccine
- https://www.nature.com/articles/s41551-024-01209-3
持続的なリンパ節拡張は治療ワクチン接種の有効性と関連する Durable lymph-node expansion is associated with the efficacy of therapeutic vaccination
Alexander J. Najibi,Ryan S. Lane,Miguel C. Sobral,Giovanni Bovone,Shawn Kang,Benjamin R. Freedman,Joel Gutierrez Estupinan,Alberto Elosegui-Artola,Christina M. Tringides,Maxence O. Dellacherie,Katherine Williams,Hamza Ijaz,Sören Müller,Shannon J. Turley &David J. Mooney
Nature Biomedical Engineering Published:06 May 2024
DOI:https://doi.org/10.1038/s41551-024-01209-3
Abstract
Following immunization, lymph nodes dynamically expand and contract. The mechanical and cellular changes enabling the early-stage expansion of lymph nodes have been characterized, yet the durability of such responses and their implications for adaptive immunity and vaccine efficacy are unknown. Here, by leveraging high-frequency ultrasound imaging of the lymph nodes of mice, we report more potent and persistent lymph-node expansion for animals immunized with a mesoporous silica vaccine incorporating a model antigen than for animals given bolus immunization or standard vaccine formulations such as alum, and that durable and robust lymph-node expansion was associated with vaccine efficacy and adaptive immunity for 100 days post-vaccination in a mouse model of melanoma. Immunization altered the mechanical and extracellular-matrix properties of the lymph nodes, drove antigen-dependent proliferation of immune and stromal cells, and altered the transcriptional features of dendritic cells and inflammatory monocytes. Strategies that robustly maintain lymph-node expansion may result in enhanced vaccination outcomes.
