2024-08-07 ノースカロライナ州立大学(NCState)
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傷口を電気的に刺激し、傷口を素早く閉鎖させる、水を動力とする電子機器不要の包帯 Water-powered, electronics-free dressings that electrically stimulate wounds for rapid wound closure
Rajaram Kaveti, Margaret A. Jakus, Henry Chen, Bhavya Jain, […], and Amay J. Bandodkar
Science Advances Published:7 Aug 2024
DOI:https://doi.org/10.1126/sciadv.ado7538
Abstract
Chronic wounds affect ~2% of the U.S. population and increase risks of amputation and mortality. Unfortunately, treatments for such wounds are often expensive, complex, and only moderately effective. Electrotherapy represents a cost-effective treatment; however, its reliance on bulky equipment limits its clinical use. Here, we introduce water-powered, electronics-free dressings (WPEDs) that offer a unique solution to this issue. The WPED performs even under harsh conditions—situations wherein many present treatments fail. It uses a flexible, biocompatible magnesium-silver/silver chloride battery and a pair of stimulation electrodes; upon the addition of water, the battery creates a radial electric field. Experiments in diabetic mice confirm the WPED’s ability to accelerate wound closure and promote healing by increasing epidermal thickness, modulating inflammation, and promoting angiogenesis. Across preclinical wound models, the WPED-treated group heals faster than the control with wound closure rates comparable to treatments requiring expensive biologics and/or complex electronics. The results demonstrate the WPED’s potential as an effective and more practical wound treatment dressing.
