2025-02-26 清華大学
<関連情報>
- https://www.tsinghua.edu.cn/en/info/1245/14102.htm
- https://www.nature.com/articles/s42255-024-01176-8
セルラー・フェイミンは筋の熱発生を抑制することで運動パフォーマンスを向上させる Cellular Feimin enhances exercise performance by suppressing muscle thermogenesis
Ying Peng,Liangjie Jia,Xiao Hu,Xiaoliu Shi,Xinlei Fang,Yifu Qiu,Zhenji Gan & Yiguo Wang
Nature Metabolism Published:02 January 2025
DOI:https://doi.org/10.1038/s42255-024-01176-8
An Author Correction to this article was published on 11 February 2025
This article has been updated
Abstract
Exercise can rapidly increase core body temperature, and research has indicated that elevated internal body temperature can independently contribute to fatigue during physical activity. However, the precise mechanisms responsible for regulating thermogenesis in muscles during exercise have remained unclear. Here, we demonstrate that cellular Feimin (cFeimin) enhances exercise performance by inhibiting muscle thermogenesis during physical activity. Mechanistically, we found that AMP-activated protein kinase (AMPK) phosphorylates cFeimin and facilitates its translocation into the cell nucleus during exercise. Within the nucleus, cFeimin binds to the forkhead transcription factor FOXC2, leading to the suppressed expression of sarcolipin (Sln), which is a key regulator of muscle thermogenesis. In addition, our results further reveal that short-term AMPK agonist treatments can enhance exercise performance through the activation of the AMPK–cFeimin signalling pathway. In summary, these results underscore the crucial role of cFeimin in enhancing exercise performance by modulating SLN-mediated thermogenesis.
