運動が視覚・聴覚情報の脳内処理に与える影響を解明(How Movement Affects the Way the Brain Processes Sound and Sight)

2025-03-26 韓国基礎科学研究院(IBS)

<関連情報>

• https://www.ibs.re.kr/cop/bbs/BBSMSTR_000000000738/selectBoardArticle.do
• https://www.nature.com/articles/s41467-025-57347-y

運動量に依存した頭頂皮質への聴覚ゲーティングが多感覚的判断を導く Locomotion-dependent auditory gating to the parietal cortex guides multisensory decisions

Ilsong Choi & Seung-Hee Lee
Nature Communications
Published:07 March 2025
DOI:https://doi.org/10.1038/s41467-025-57347-y

Abstract

Decision-making in mammals fundamentally relies on integrating multiple sensory inputs, with conflicting information resolved flexibly based on a dominant sensory modality. However, the neural mechanisms underlying state-dependent changes in sensory dominance remain poorly understood. Our study demonstrates that locomotion in mice shifts auditory-dominant decisions toward visual dominance during audiovisual conflicts. Using circuit-specific calcium imaging and optogenetic manipulations, we found that weakened visual representation in the posterior parietal cortex (PPC) leads to auditory-dominant decisions in stationary mice. Prolonged locomotion, however, promotes visual dominance by inhibiting auditory cortical neurons projecting to the PPC (AC_PPC). This shift is mediated by secondary motor cortical neurons projecting to the auditory cortex (M2_AC), which specifically inhibit AC_PPC neurons without affecting auditory cortical projections to the striatum (AC_STR). Our findings reveal the neural circuit mechanisms underlying auditory gating to the association cortex depending on locomotion states, providing insights into the state-dependent changes in sensory dominance during multisensory decision-making.