2025-04-03 中国科学院(CAS)
<関連情報>
- https://english.cas.cn/newsroom/research_news/life/202503/t20250331_908983.shtml
- https://www.science.org/doi/10.1126/sciadv.ads1341
亜鉛飢餓応答と二次代謝を制御する概日時計は真菌の病原性に重要である Circadian clock is critical for fungal pathogenesis by regulating zinc starvation response and secondary metabolism
Qiaojia Lu, Muqun Yu, Xianyun Sun, Xin Zhou, […], and Xiao Liu
Science Advances Published:28 Mar 2025
DOI:https://doi.org/10.1126/sciadv.ads1341
Abstract
Circadian clocks are known to modulate host immune responses to pathogen infections, yet their role in influencing pathogen pathogenesis remains unclear. Here, we investigated the role of circadian clocks in regulating the pathogenesis of the fungal pathogen Fusarium oxysporum, which has multiple genes homologous to the Neurospora crassa frq due to gene duplication events, with Fofrq1 being the primary circadian clock gene. The pathogenesis of F. oxysporum in plants is controlled by its circadian clock, with infections causing severe disease symptoms at dawn. Notably, disruption of clock genes dramatically reduces fungal pathogenicity. Circadian clocks regulate the rhythmic expression of several transcription factors, including FoZafA, which enables the pathogen to adapt to zinc starvation within the plant, and FoCzf1, which governs the production of the toxin fusaric acid. Together, our findings highlight the critical roles of circadian clocks in F. oxysporum pathogenicity by regulating zinc starvation response and secondary metabolite production.
