2025-04-22 オックスフォード大学
<関連情報>
- https://www.ox.ac.uk/news/2025-04-22-new-ultrasound-drug-delivery-system-found-be-highly-effective-against-bacterial
- https://www.nature.com/articles/s44259-025-00086-3
標的バイオフィルム薬物送達のための超音波トリガー・ナノスケール・システムによる抗菌薬の再利用 Repurposing antimicrobials with ultrasound-triggered nanoscale systems for targeted biofilm drug delivery
Victor Choi,Dario Carugo & Eleanor Stride
npj Antimicrobials and Resistance Published:01 April 2025
DOI:https://doi.org/10.1038/s44259-025-00086-3
Abstract
Chronic infections represent a major clinical challenge due to the enhanced antimicrobial tolerance of biofilm-dwelling bacteria. To address this challenge, an ultrasound-responsive nanoscale drug delivery platform (nanodroplets) is presented in this work, loaded with four different antimicrobial agents, capable of simultaneous biofilm disruption and targeted antimicrobial delivery. When loaded, a robust protective effect against clinically-derived MRSA and ESBL Gram-positive and Gram-negative planktonic isolates was shown in vitro. Upon application of therapeutic ultrasound, an average 7.6-fold, 44.4-fold, and 25.5-fold reduction was observed in the antibiotic concentrations compared to free drug required to reach the MBC, MBEC and complete persister eradication levels, respectively. Nanodroplets substantially altered subcellular distribution of encapsulated antimicrobials, enhancing accumulation of antimicrobials by 11.1-fold within the biofilm-residing bacteria’s cytoplasm compared to treatment with unencapsulated drugs. These findings illustrate the potential of this multifunctional platform to overcome the critical penetration and localization limitations of antimicrobials within biofilms, opening potential new avenues in the treatment of chronic clinical infections.
