2025-05-01 カナダ・ブリティッシュコロンビア大学(UBC)
<関連情報>
- https://news.ubc.ca/2025/05/inflammatory-bowel-disease-treatments-glycocaging/
- https://www.science.org/doi/10.1126/science.adk7633
腸内細菌叢を介した薬物ターゲティングのためのオーダーメイドの植物性糖鎖複合体 Bespoke plant glycoconjugates for gut microbiota-mediated drug targeting
Wei Jen Ma, Changqing Wang, Jagatheeswaran Kothandapani, Matthew Luzentales-Simpson, […] , and Harry Brumer
Science Published:1 May 2025
DOI:https://doi.org/10.1126/science.adk7633
Abstract
The gut microbiota of mammals possess unique metabolic pathways with untapped therapeutic potential. Using molecular insights into dietary fiber metabolism by the human gut microbiota, we designed a targeted drug delivery system based on bespoke glycoconjugates of a complex plant oligosaccharide called GlycoCaging. GlycoCaging of exemplar anti-inflammatory drugs enabled release of active molecules triggered by unique glycosidases of autochthonous gut bacteria. GlycoCaging ensured drug efficacy was potentiated, and off-target effects were eliminated in murine models of inflammatory bowel disease. Biochemical and metagenomic analyses of gut microbiota of individual humans confirmed the broad applicability of this strategy.
