2025-07-15 中国科学院(CAS)
<関連情報>
- https://english.cas.cn/newsroom/research_news/life/202507/t20250718_1047595.shtml
- https://faseb.onlinelibrary.wiley.com/doi/10.1096/fj.202403082R
クコ多糖体はノギンを標的として後肢負荷解除による骨量減少を改善する Lycium barbarum Polysaccharide Ameliorates Hindlimb Unloading-Induced Bone Loss by Targeting Noggin
Chuanxin Sun, Yuke He, Xia Chen, Kan Ding, Chang Chen
The FASEB JournalPublished: 10 July 2025
DOI:https://doi.org/10.1096/fj.202403082R
Graphical Abstract
This is the first study to examine the effects of Lycium barbarum on disuse bone loss. To examine the effects of disuse, microgravity was simulated in vivo using hindlimb unloading in young male mice and in vitro rotary MC3T3-E1 osteoblastic cell culture system. Lycium barbarum polysaccharide (LBPP) is the active ingredient mediating these effects. LBPP directly binds to noggin, facilitating the phosphorylation of downstream Smads to stimulate bone formation. These findings demonstrate the potential of Lycium barbarum as a functional food for preventing disuse bone loss and provide a theoretical basis for its therapeutic applications.
ABSTRACT
Disuse bone loss is a common metabolic bone disease with limited effective, safe treatments. Lycium barbarum (L. barbarum), a traditional Chinese medicine and popular health food, has been historically noted in Ben Cao Gang Mu (Compendium of Materia Medica) for its bone-strengthening properties. However, the effects of L. barbarum on disuse bone loss and the underlying mechanisms remain unclear. This study used a hindlimb-unloading mouse model and a simulated microgravity model of MC3T3-E1 cells in a rotary cell culture system to investigate the role of L. barbarum water extract (LBE) and polysaccharide (LBP). LBE and LBP significantly enhanced bone mass and strength in hindlimb-unloaded mice. Further analysis identified a polysaccharide component, LBPP, as the active ingredient mediating these effects. LBPP enhanced osteoblast differentiation and ossification under normal conditions and promoted osteoblast activity under simulated microgravity. Mechanistic studies revealed that LBPP directly binds to noggin, a potent inhibitor of BMPs, facilitating phosphorylation of downstream Smads to stimulate bone formation. These findings demonstrate the potential of L. barbarum as a functional food for preventing disuse bone loss and provide a theoretical basis for its therapeutic applications.
