2025-07-24 シンガポール国立大学(NUS)
<関連情報>
- https://news.nus.edu.sg/new-applications-of-magnetic-field-therapy-in-muscle-metabolic-health/
- https://www.mdpi.com/1422-0067/26/12/5450
- https://www.mdpi.com/1422-0067/26/11/5423
磁気ミトホルメシス治療を受けたマウスからの糞便微生物叢移植は、高脂肪食誘発性代謝異常と骨形成障害を逆転させる Fecal Microbiota Transplantation from Mice Receiving Magnetic Mitohormesis Treatment Reverses High-Fat Diet-Induced Metabolic and Osteogenic Dysfunction
Jun Kit Craig Wong,Bharati Kadamb Patel,Yee Kit Tai,Tuan Zea Tan,Wei Wei Thwe Khine,Way Cherng Chen,Marek Kukumberg,Jianhong Ching,Lye Siang Lee,Kee Voon Chua,Tsze Yin Tan,Kwan Yu Wu,Xizhe Bai,Jan Nikolas Iversen,Kristy Purnamawati,Rufaihah Abdul Jalil,Alan Prem Kumar,Yuan Kun Lee,Shabbir M. Moochhala andAlfredo Franco-Obregón
International Journal of Molecular Sciences Published: 6 June 2025
DOI:https://doi.org/10.3390/ijms26125450
Graphical Abstract
Abstract
This study compared the metabolic consequences of fecal microbiota transplantation (FMT) from donor mice that had been either administered pulsed electromagnetic field (PEMF) therapy or exercised to recipient mice fed a high-fat diet (HFD). Eight weeks of PEMF treatment (10 min/week) enhanced PGC-1α-associated mitochondrial and metabolic gene expression in white and brown adipose to a greater degree than eight weeks of exercise (30–40 min/week). FMT from PEMF-treated donor mice recapitulated these adipogenic adaptations in HFD-fed recipient mice more faithfully than FMT from exercised donors. Direct PEMF treatment altered hepatic phospholipid composition, reducing long-chain ceramides (C16:0) and increasing very long-chain ceramides (C24:0), which could be transferred to PEMF-FMT recipient mice. FMT from PEMF-treated mice was also more effective at recovering glucose tolerance than FMT from exercised mice. PEMF treatment also enhanced bone density in both donor and HFD recipient mice. The gut Firmicutes/Bacteroidetes (F/B) ratio was lowest in both the directly PEMF-exposed and PEMF-FMT recipient mouse groups, consistent with a leaner phenotype. PEMF treatment, either directly applied or via FMT, enhanced adipose thermogenesis, ceramide levels, bone density, hepatic lipids, F/B ratio, and inflammatory blood biomarkers more than exercise. PEMF therapy may represent a non-invasive and non-strenuous method to ameliorate metabolic disorders.
週単位の短時間の磁場曝露は、胚発生中に鳥類の酸化性筋特性を強化する Brief Weekly Magnetic Field Exposure Enhances Avian Oxidative Muscle Character During Embryonic Development
Jasmine Lye Yee Yap,Kwan Yu Wu,Yee Kit Tai,Charlene Hui Hua Fong,Neha Manazir,Anisha Praiselin Paul,Olivia Yeo andAlfredo Franco-Obregón
International Journal of Molecular Sciences Published: 5 June 2025
DOI:https://doi.org/10.3390/ijms26115423
Abstract
Maternal metabolic dysfunction adversely influences embryonic muscle oxidative capacity and mitochondrial biogenesis, increasing the child’s long-term risks of developing obesity and metabolic syndrome in later life. This pilot study explored the mechanistic basis of embryonic muscle metabolic programming, employing non-invasive magnetic field exposures. Brief (10 min) exposure to low-energy (1.5 milliTesla at 50 Hertz) pulsing electromagnetic fields (PEMFs) has been shown in mammals to promote oxidative muscle development, associated with enhanced muscular mitochondriogenesis, augmented lipid metabolism, and attenuated inflammatory status. In this study, quail eggs were used as a model system to investigate the potential of analogous PEMF therapy to modulate embryonic muscle oxidative capacity independently of maternal influence. Quail eggs were administered five 10-min PEMF exposures to either upward-directed or downward-directed magnetic fields over 13 days. Embryos receiving magnetic treatment exhibited increased embryo weight, size, and survival compared to non-exposed controls. Upward exposure was associated with larger embryos, redder breast musculature, and upregulated levels of PPAR-α and PGC-1α, transcriptional regulators promoting oxidative muscle development, mitochondriogenesis, and angiogenesis, whereas downward exposure augmented collagen levels and reduced angiogenesis. Exposure to upward PEMFs may hence serve as a method to promote embryonic growth and oxidative muscle development and improve embryonic mortality.
