2025-08-20 中国科学院(CAS)
<関連情報>
- https://english.cas.cn/newsroom/research_news/life/202508/t20250820_1051073.shtml
- https://www.cell.com/molecular-plant/abstract/S1674-2052(25)00268-0
HDT2を介したリシン脱アセチル化は、アラブidopsisにおける光形態形成中にフィトクロムAの分解を促進する HDT2-mediated lysine deacetylation promotes phytochrome A degradation during photomorphogenesis in Arabidopsis
Feng Zheng ∙ Wenli Ou ∙ Ling Deng ∙ … ∙ Yongyi Yang ∙ Jaime A. Teixeira da Silva ∙ Xuncheng Liu
Molecular Plant Published:August 6, 2025
DOI:https://doi.org/10.1016/j.molp.2025.08.002
Abstract
The switch from skotomorphogenesis to photomorphogenesis, a key developmental transition in the life cycle of seed plants, involves dramatic proteomic changes. Lysine acetylation (Lys-Ac) is an evolutionarily conserved and widely recognized post-translational modification that plays an important role in plant development, whereas its role in seedling deetiolation remains unclear. Here, we conducted a comparative lysine acetylomic analysis of etiolated Arabidopsis seedlings before and after red (R) light irradiation, revealing that exposure to R light mainly led to widespread protein lysine deacetylation during seedling deetiolation. Phytochrome A (phyA), the unique far-red (FR) light photoreceptor, was deacetylated at lysine 65 (K65) when etiolated seedlings were transferred to light. This residue served as a critical ubiquitination site that regulates phyA stability. Furthermore, K65 deacetylation facilitates phyA ubiquitination and 26S proteasome-mediated degradation, and is essential for the function of phyA in FR light signaling and seedling photomorphogenesis. We identified a plant-specific lysine deacetylase HDT2 that interacts with and deacetylates phyA in the nucleus, thereby promoting the ubiquitination and degradation of phyA during seedling deetiolation. Genetic analysis revealed that HDT2 plays a crucial role in phyA-mediated photomorphogenic growth. These findings suggest that lysine deacetylation of phyA by HDT2 plays an essential role in modulating phyA turnover in response to light, revealing that Lys-Ac is central to the rewiring of plants for photomorphogenic growth.
