2025-09-08 カリフォルニア大学バークレー校 (UCB)
Researchers recorded brain activity in sleeping and awake mice while stimulating neurons in the brain’s hypothalamus.
Yang Dan lab/UC Berkeley
<関連情報>
- https://news.berkeley.edu/2025/09/08/sleep-strengthens-muscle-and-bone-by-boosting-growth-hormone-levels-uc-berkeley-researchers-discover-how/
- https://www.cell.com/cell/fulltext/S0092-8674(25)00626-9
睡眠依存性成長ホルモン放出の神経内分泌回路 Neuroendocrine circuit for sleep-dependent growth hormone release
Xinlu Ding ∙ Fuu-Jiun Hwang ∙ Daniel Silverman ∙ … ∙ Zhiyu Melissa Tian ∙ Jun Ding, ∙ Yang Dan
Cell Published:June 24, 2025
DOI:https://doi.org/10.1016/j.cell.2025.05.039
Highlights
- Sleep-dependent GH release is regulated by distinct GHRH and SST hypothalamic neurons
- SST neurons in ARC suppress GH release by inhibiting GHRH neurons that are stimulatory
- SST neurons in PeV suppress GH release through their projections to the median eminence
- Feedback pathway with GH enhancing LC neuron excitability and promoting wakefulness
Summary
Sleep is known to promote tissue growth and regulate metabolism, partly by enhancing growth hormone (GH) release, but the underlying circuit mechanism is unknown. We demonstrate how GH release, which is enhanced during both rapid eye movement (REM) and non-REM (NREM) sleep, is regulated by sleep-wake-dependent activity of distinct hypothalamic neurons expressing GH-releasing hormone (GHRH) and somatostatin (SST). SST neurons in the arcuate nucleus suppress GH release by inhibiting nearby GHRH neurons that stimulate GH release, whereas periventricular SST neurons inhibit GH release by projecting to the median eminence. GH release is associated with strong surges of both GHRH and SST activity during REM sleep but moderately increased GHRH and decreased SST activity during NREM sleep. Furthermore, we identified a negative feedback pathway in which GH enhances the excitability of locus coeruleus neurons and increases wakefulness. These results elucidate a circuit mechanism underlying bidirectional interactions between sleep and hormone regulation.
