2025-10-01 カリフォルニア大学アーバイン校 (UCI)
The analysis revealed substantial alterations in brain shape, which were closely associated with declines in memory, reasoning and other cognitive functions. This suggests that the shape of the brain can serve as a reliable indicator of its overall health. Steve Zylius / UC Irvine
<関連情報>
- https://news.uci.edu/2025/10/01/brain-shape-changes-could-offer-early-warning-signs-of-dementia/
- https://www.nature.com/articles/s41467-025-63628-3
- https://www.nature.com/articles/s41467-025-63628-3.epdf
脳の空間幾何学における加齢による制約 Age-related constraints on the spatial geometry of the brain
Yuritza Y. Escalante,Jenna N. Adams,Michael A. Yassa & Niels Janssen
Nature Communications Published:29 September 2025
DOI:https://doi.org/10.1038/s41467-025-63628-3
Abstract
Age-related structural brain changes may be better captured by assessing complex spatial geometric differences rather than isolated changes to individual regions. We applied an analytic method to quantify age-related changes to the spatial anatomy of the brain by measuring expansion and compression of global brain shape and the distance between cross-hemisphere homologous regions. To test how global brain shape and regional distances are affected by aging, we analyzed 2603 structural MRIs (range: 30-97 years). Increasing age was associated with global expansion across inferior-anterior gradients, global compression across superior-posterior gradients, and regional expansion between frontotemporal homologues. Specific patterns of global and regional expansion and compression were further associated with clinical impairment and distinctly related to deficits in various cognitive domains. These findings suggest that changes to the complex spatial anatomy and geometry of the aging brain may be associated with reduced efficiency and cognitive dysfunction in older adults.
